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The Journal of Thoracic and Cardiovascular Surgery, Vol 81, 813-817, Copyright © 1981 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Prospective, randomized, double-blind study using prophylactic cephalothin for major, elective, general thoracic operations

R Ilves, JD Cooper, TR Todd and FG Pearson

A total of 211 patients were entered into a randomized, double-blind study of postoperative infection in which an antibiotic (cephalothin) and a placebo were used. The antibiotic was effective in reducing sleep wound infections (p less than 0.05) and superficial wound infections (p less than 0.01). The incidence of pulmonary infections was decreased, but the change was not statistically significant, and the incidence of empyema was unaffected.


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