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The Journal of Thoracic and Cardiovascular Surgery, Vol 84, 601-608, Copyright © 1982 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
A Faichney, KG Davidson, DJ Wheatley, JF Davidson and ID Walker
The effects of prostacyclin (PGI2) on postoperative blood loss and on the
deposits which are known to form on filters in the bypass circuit were
studied in patients undergoing operations with cardioopulmonary bypass. In
this double-blind, randomized study, PGI2 or a placebo solution was
administered to 56 patients undergoing elective cardiac operations. At the
end of cardipulmonary bypass, the arterial line filter was removed from the
circuit and blood losses were accurately recorded. There was no
statistically significant difference in either the amount or the pattern of
postbypass bleeding between the PGI2 and the control patients. However, the
changes in weight of the arterial line filters and their electron
microscopic appearances suggest that PGI2 can reduce the deposition of
platelets and fibrin on the filter mesh, and in this role it may be of
value in reducing visceral injury during cardiac operations.
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Prostacyclin in cardiopulmonary bypass operations
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