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The Journal of Thoracic and Cardiovascular Surgery, Vol 84, 897-905, Copyright © 1982 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Protection of the myocardium against postischemic reperfusion damage. The combined effect of hypothermia and nifedipine

WG Nayler

This study tests the hypothesis that the efficacy of hypothermia as a cardiacprotective agent can be increased by adding the slow channel-- blocking agent, nifedipine. Isolated, electrically paced rabbit hearts were made ischemic for 60 to 180 minutes at 37 degrees, 34 degrees, 28 degrees, 25 degrees, 15 degrees, 12 degrees, and 5 degrees C and then reperfused at 37 degrees C. Recovery was assessed in terms of recovery of mechanical function, tissue stores of adenosine triphosphate (ATP), oxidative phosphorylative and ATP-generating capacity of the mitochondria, and mitochondrial Ca2+ content. Half of the hearts received 50 micrograms/L nifedipine. The results show that the protective effects of hypothermia and nifedipine are additive.

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