HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lurie, K. G. Articles by Reitz, B. A. Search for Related Content PubMed PubMed Citation Articles by Lurie, K. G. Articles by Reitz, B. A.

The Journal of Thoracic and Cardiovascular Surgery, Vol 86, 195-201, Copyright © 1983 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Increased beta-adrenergic receptor density in an experimental model of cardiac transplantation

KG Lurie, MR Bristow and BA Reitz

We examined beta-adrenergic receptor density, basal, maximal isoproterenol and fluoride-stimulated adenylate cyclase activities, and morphologic characteristics of rabbit and rat native and heterotopic isograft cardiac tissue. Four weeks after graft placement there were only subtle histologic differences between native and graft tissue. Membrane preparations from isografts of rabbits demonstrated increases in beta-receptor density (maximum [3H]DHA binding = 111 +/- 19.3 fmol/mg versus 52.4 +/- 4.9 in native hearts, p less than 0.05). In a small number of experiments, rat isografts also demonstrated a suggestive increase in beta-receptor density (69.8 +/- 7.1 fmol/mg versus 40.2 +/- 7.3 in native hearts). Isoproterenol-stimulated adenylate cyclase activity was greater in rabbit graft hearts (3.98 +/- 0.20 X basal activity) than in native tissue 2.67 +/- 0.16 X basal activity, p less than 0.05). We conclude that cardiac denervation may lead to a postsynaptic form of beta-adrenergic supersensitivity that is due to an increase in beta-receptor density.

This article has been cited by other articles:

				A. Y. Sheikh, M. P. Pelletier, and R. C. Robbins Heart-Lung and Lung Transplantation Card. Surg. Adult, January 1, 2008; 3(2008): 1579 - 1608. [Full Text]

				L. B. Balsam, D. D. Yuh, R. C. Robbins, and B. A. Reitz Heart-Lung and Lung Transplantation Card. Surg. Adult, January 1, 2003; 2(2003): 1461 - 1490. [Full Text]

				G. Munch, N. T. B. Nguyen, S. Nekolla, S. Ziegler, O. Muzik, P. Chakraborty, D. M. Wieland, and M. Schwaiger Evaluation of Sympathetic Nerve Terminals With [11C]Epinephrine and [11C]Hydroxyephedrine and Positron Emission Tomography Circulation, February 8, 2000; 101(5): 516 - 523. [Abstract] [Full Text] [PDF]

				K. O. Akosah, B. Denlinger, and P. K. Mohanty Safety Profile and Hemodynamic Responses to {beta}-Adrenergic Stimulation by Dobutamine in Heart Transplant Patients* Chest, December 1, 1999; 116(6): 1587 - 1592. [Abstract] [Full Text] [PDF]

				C.-W. Chiou, J. N. Eble, and D. P. Zipes Efferent Vagal Innervation of the Canine Atria and Sinus and Atrioventricular Nodes: The Third Fat Pad Circulation, June 3, 1997; 95(11): 2573 - 2584. [Abstract] [Full Text]

				F. L. Atkins, O. H. L. Bing, P. G. DiMauro, C. H. Conrad, K. G. Robinson, and W. W. Brooks Modulation of Left and Right Ventricular -Adrenergic Receptors From Spontaneously Hypertensive Rats With Left Ventricular Hypertrophy and Failure Hypertension, July 1, 1995; 26(1): 78 - 82. [Abstract] [Full Text]

				E. Loh, J. V. Barnett, A. M. Feldman, G. S. Couper, D. E. Vatner, W. S. Colucci, and J. B. Galper Decreased Adenylate Cyclase Activity and Expression of Gs{alpha} in Human Myocardium After Orthotopic Cardiac Transplantation Circ. Res., May 1, 1995; 76(5): 852 - 860. [Abstract] [Full Text]

				E. De Broux, G. Lagace, and C. Chartand Efficacy of isoproterenol on the failing transplanted heart during early acute rejection Ann. Thorac. Surg., June 1, 1992; 53(6): 1062 - 1067. [Abstract] [PDF]