| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Thoracic and Cardiovascular Surgery, Vol 86, 845-857, Copyright © 1983 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
JK Kirklin, S Westaby, EH Blackstone, JW Kirklin, DE Chenoweth and AD Pacifico
Postoperative cardiac, pulmonary, renal and coagulation dysfunction, along
with C3a levels, were studied prospectively in 116 consecutive patients
undergoing open cardiac operations and 12 patients undergoing closed
operations in the same time period. The level of C3a 3 hours after open
operation was high (median value 882 ng X ml-1 plasma) and was related to
the C3a level before cardiopulmonary bypass (CPB) (p = 0.03), the level at
the end of CPB (p less than 0.0001), elapsed time of CPB (p = 0.07), and
older age at operation (p less than 0.0001). It was inversely related to
the cardiac output as reflected by the strength of the pedal pulses (p =
0.006). In contrast, C3a levels did not rise in patients undergoing closed
operations. The probability of postoperative cardiac dysfunction after open
operations (present in 27 of 116 patients) was predicted by C3a levels 3
hours after operation (p = 0.02), the CPB time (p = 0.02), and younger age
(p less than 0.0001). The same risk factors pertained for postoperative
pulmonary dysfunction (present in 41 of the 116 patients); renal
dysfunction (present in 24 of the 116 patients) except that CPB time was
not a risk factor here; abnormal bleeding (present in 21 of the 116
patients); and important overall morbidity (present in 26 of 116 patients).
As regards important overall morbidity, the C3a level effect became evident
at about 1,900 ng X ml-1 (a level reached by 9% of patients); the effect of
increasing time of CPB became evident at about 90 minutes of CPB time; and
the effect of young age became evident as age decreased from 10 to 4 years.
This study demonstrates the damaging effects of CPB, relates them in part
to complement activation by the foreign surfaces encountered by the blood,
and supports the hypothesis that the mechanisms of the damaging effects
include a whole-body inflammatory reaction.
ARTICLES
Complement and the damaging effects of cardiopulmonary bypass
This article has been cited by other articles:
|
|
 |
|
  S. Yamazaki, S. Inamori, T. Nakatani, and M. Suga Activated protein C attenuates cardiopulmonary bypass-induced acute lung injury through the regulation of neutrophil activation J. Thorac. Cardiovasc. Surg., May 1, 2011; 141(5): 1246 - 1252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. M. Bechtel, S. Muhlenbein, W. Eichler, M. Marx, and H.-H. Sievers Leukocyte depletion during cardiopulmonary bypass in routine adult cardiac surgery Interact CardioVasc Thorac Surg, February 1, 2011; 12(2): 207 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Ensor, R. T. Sabo, and S. A. Voils Impact of Early Postoperative Hydrocortisone Administration in Cardiac Surgical Patients After Cardiopulmonary Bypass Ann. Pharmacother., February 1, 2011; 45(2): 189 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. K. Allan, J. W. Newburger, E. McGrath, J. Elder, C. Psoinos, P. C. Laussen, P. J. del Nido, D. Wypij, and F. X. McGowan Jr. The Relationship Between Inflammatory Activation and Clinical Outcome After Infant Cardiopulmonary Bypass Anesth. Analg., November 1, 2010; 111(5): 1244 - 1251. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Albu, B. Babik, K. Kesmarky, M. Balazs, Z. Hantos, and F. Petak Changes in Airway and Respiratory Tissue Mechanics After Cardiac Surgery Ann. Thorac. Surg., April 1, 2010; 89(4): 1218 - 1226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Hoedemaekers, M. van Deuren, T. Sprong, P. Pickkers, T.-E. Mollnes, I. Klasen, and J. van der Hoeven The Complement System Is Activated in a Biphasic Pattern After Coronary Artery Bypass Grafting Ann. Thorac. Surg., March 1, 2010; 89(3): 710 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kagawa, K. Morita, R. Nagahori, G. Shinohara, K. Kinouchi, and K. Hashimoto Prevention of ischemia/reperfusion-induced pulmonary dysfunction after cardiopulmonary bypass with terminal leukocyte-depleted lung reperfusion J. Thorac. Cardiovasc. Surg., January 1, 2010; 139(1): 174 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. E. Hussaini, P. R. Treanor, N. A. Healey, D. Tilahun, R. Srey, X.-G. Lu, S. F. Khuri, and H. S. Thatte Evaluation of blood components exposed to coated arterial filters in extracorporeal circuits Perfusion, September 1, 2009; 24(5): 317 - 323. [Abstract] [PDF]
|
|
|
|
|
|
S Blomquist, V Gustafsson, T Manolopoulos, and L Pierre Clinical experience with a novel endotoxin adsorbtion device in patients undergoing cardiac surgery Perfusion, January 1, 2009; 24(1): 13 - 17. [Abstract] [PDF]
|
|
|
|
|
|
W. Osthaus, H Gorler, J Sievers, N Rahe-Meyer, J Optenhofel, T Breymann, G Theilmeier, and R Suempelmann Bicarbonate-buffered ultrafiltration during pediatric cardiac surgery prevents electrolyte and acid-base balance disturbances Perfusion, January 1, 2009; 24(1): 19 - 25. [Abstract] [PDF]
|
|
|
|
|
|
J. van den Goor, B. Saxby, J. Tijssen, K. Wesnes, B. de Mol, and R Nieuwland Improvement of cognitive test performance in patients undergoing primary CABG and other CPB-assisted cardiac procedures Perfusion, September 1, 2008; 23(5): 267 - 273. [Abstract] [PDF]
|
|
|
|
|
|
K Svennevig, T. Hoel, A. Thiara, S. Kolset, A Castelheim, T. Mollnes, F Brosstad, E Fosse, and J. Svennevig Syndecan-1 plasma levels during coronary artery bypass surgery with and without cardiopulmonary bypass Perfusion, May 1, 2008; 23(3): 165 - 171. [Abstract] [PDF]
|
|
|
|
 |
|
 P. Pepino, P. Oliviero, F. Petteruti, L. di Tommaso, M. Monaco, and P. Stassano Left Heart Pump-Assisted Beating Heart Coronary Surgery in High-Risk Patients Asian Cardiovasc Thorac Ann, April 1, 2008; 16(2): 159 - 161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Rosner, D. Portilla, and M. D. Okusa Analytic Reviews: Cardiac Surgery as a Cause of Acute Kidney Injury: Pathogenesis and Potential Therapies J Intensive Care Med, January 1, 2008; 23(1): 3 - 18. [Abstract] [PDF]
|
|
|
|
 |
|
 J. W. Hammon Extracorporeal Circulation: The Response of Humoral and Cellular Elements of Blood to Extracorporeal Circulation Card. Surg. Adult, January 1, 2008; 3(2008): 370 - 389. [Full Text]
|
|
|
|
 |
|
 A. Radaelli, C. Loardi, M. Cazzaniga, G. Balestri, C. DeCarlini, M. G. Cerrito, E. N. Cusa, L. Guerra, S. Garducci, D. Santo, et al. Inflammatory Activation During Coronary Artery Surgery and Its Dose-Dependent Modulation by Statin/ACE-Inhibitor Combination Arterioscler Thromb Vasc Biol, December 1, 2007; 27(12): 2750 - 2755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Thiele, R. W. Smalling, and G. C. Schuler Percutaneous left ventricular assist devices in acute myocardial infarction complicated by cardiogenic shock Eur. Heart J., September 1, 2007; 28(17): 2057 - 2063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. N. Hoel, V. Videm, T. E. Mollnes, K. Saatvedt, F. Brosstad, A. E. Fiane, E. Fosse, and J. L. Svennevig Off-pump cardiac surgery abolishes complement activation Perfusion, July 1, 2007; 22(4): 251 - 256. [Abstract] [PDF]
|
|
|
|
|
|
A. Sarajuuri, E. Jokinen, R. Puosi, M. Eronen, L. Mildh, I. Mattila, L. Valanne, and T. Lonnqvist Neurodevelopmental and neuroradiologic outcomes in patients with univentricular heart aged 5 to 7 years: Related risk factor analysis J. Thorac. Cardiovasc. Surg., June 1, 2007; 133(6): 1524 - 1532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Baig, R. Nassar, D. M. Craig, G. Quick Jr, H. X. Jiang, M. M. Frank, A. J. Lodge, P. A.W. Anderson, and J. Jaggers Complement Factor 1 Inhibitor Improves Cardiopulmonary Function in Neonatal Cardiopulmonary Bypass Ann. Thorac. Surg., April 1, 2007; 83(4): 1477 - 1483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Just, T. Muller, and J. M. Albes Minimized closed circuit/centrifugal pump extracorporeal circulation: an effective aid in coronary bypass operations in Jehovah's Witnesses Interact CardioVasc Thorac Surg, February 1, 2007; 6(1): 124 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Just, T. Muller, M. Hartrumpf, and J. M. Albes First experience with closed circuit/centrifugal pump extracorporeal circulation: cellular trauma, coagulatory, and inflammatory response Interact CardioVasc Thorac Surg, October 1, 2006; 5(5): 646 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. G. Shann, D. S. Likosky, J. M. Murkin, R. A. Baker, Y. R. Baribeau, G. R. DeFoe, T. A. Dickinson, T. J. Gardner, H. P. Grocott, G. T. O'Connor, et al. An evidence-based review of the practice of cardiopulmonary bypass in adults: A focus on neurologic injury, glycemic control, hemodilution, and the inflammatory response. J. Thorac. Cardiovasc. Surg., August 1, 2006; 132(2): 283 - 290.e3. [Full Text] [PDF]
|
|
|
|
|
|
C. A. Skrabal, Y. H. Choi, A. Kaminski, M. Steiner, G. Kundt, G. Steinhoff, and A. Liebold Circulating endothelial cells demonstrate an attenuation of endothelial damage by minimizing the extracorporeal circulation. J. Thorac. Cardiovasc. Surg., August 1, 2006; 132(2): 291 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Onorati, L. Cristodoro, M. Bilotta, B. Impiombato, F. Pezzo, P. Mastroroberto, A. di Virgilio, and A. Renzulli Intraaortic Balloon Pumping During Cardioplegic Arrest Preserves Lung Function in Patients With Chronic Obstructive Pulmonary Disease Ann. Thorac. Surg., July 1, 2006; 82(1): 35 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. De Silva, A. Vuylsteke, S. J. Fritchley, A. K. Trull, J. J. Dunning, and J. Wallwork APT070 inhibits complement activation during in vitro cardiopulmonary bypass Eur J Cardiothorac Surg, July 1, 2006; 30(1): 72 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Hogue Jr, C. A. Palin, and J. E. Arrowsmith Cardiopulmonary Bypass Management and Neurologic Outcomes: An Evidence-Based Appraisal of Current Practices Anesth. Analg., July 1, 2006; 103(1): 21 - 37. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Kozik and J. S. Tweddell Characterizing the Inflammatory Response to Cardiopulmonary Bypass in Children Ann. Thorac. Surg., June 1, 2006; 81(6): S2347 - S2354. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-Y. Hsia and P. J. Gruber Factors Influencing Neurologic Outcome After Neonatal Cardiopulmonary Bypass: What We Can and Cannot Control Ann. Thorac. Surg., June 1, 2006; 81(6): S2381 - S2388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Vassiliades Jr, J. S. Douglas, D. C. Morris, P. C. Block, Z. Ghazzal, S. T. Rab, and C. U. Cates Integrated coronary revascularization with drug-eluting stents: Immediate and seven-month outcome J. Thorac. Cardiovasc. Surg., May 1, 2006; 131(5): 956 - 962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Draaisma, M. G. Hazekamp, N. Anes, P. H. Schoof, C. E. Hack, A. Sturk, and R. A. E. Dion Phosphorylcholine Coating of Bypass Systems Used for Young Infants Does Not Attenuate the Inflammatory Response Ann. Thorac. Surg., April 1, 2006; 81(4): 1455 - 1459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Beholz, S. Dushe, and W. Konertz Continuous Suture Technique for Freedom Stentless Valve: Reduced Crossclamp Time Asian Cardiovasc Thorac Ann, April 1, 2006; 14(2): 128 - 133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-S. Wong, A. Asmat, Y.-H. Chan, and C.-N. Lee A randomized, double-blind, placebo-controlled trial of a COX-2 inhibitor (Rofecoxib) in patients undergoing coronary artery bypass surgery Interact CardioVasc Thorac Surg, April 1, 2006; 5(2): 101 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Gersbach, H. Tevaearai, J.-P. Revelly, P. Bize, R. Chiolero, and L. K. von Segesser Are there accurate predictors of long-term vital and functional outcomes in cardiac surgical patients requiring prolonged intensive care? Eur J Cardiothorac Surg, April 1, 2006; 29(4): 466 - 472. [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Roth, I. Adatia, G. D. Pearson, and and Members of the Cardiology Group Summary Proceedings From the Cardiology Group on Postoperative Cardiac Dysfunction Pediatrics, March 1, 2006; 117(Supplement_1): S40 - S46. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Schultz, T. Karamlou, J. Swanson, I. Shen, and R. M. Ungerleider Hypothermic Low-Flow Cardiopulmonary Bypass Impairs Pulmonary and Right Ventricular Function More Than Circulatory Arrest Ann. Thorac. Surg., February 1, 2006; 81(2): 474 - 480. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. Rosner and M. D. Okusa Acute Kidney Injury Associated with Cardiac Surgery Clin. J. Am. Soc. Nephrol., January 1, 2006; 1(1): 19 - 32. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Hassanein, A. A. Albert, B. Arnrich, J. Walter, I. C. Ennker, U. Rosendahl, S. Bauer, and J. Ennker Intraoperative Transit Time Flow Measurement: Off-Pump Versus On-Pump Coronary Artery Bypass Ann. Thorac. Surg., December 1, 2005; 80(6): 2155 - 2161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Fung, R. R. Fiscus, A. P. C. Yim, G. D. Angelini, and A. A. Arifi The Potential Use of Type-5 Phosphodiesterase Inhibitors in Coronary Artery Bypass Graft Surgery Chest, October 1, 2005; 128(4): 3065 - 3073. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Schlensak and F. Beyersdorf Lung injury during CPB: pathomechanisms and clinical relevance Interact CardioVasc Thorac Surg, October 1, 2005; 4(5): 381 - 382. [Full Text] [PDF]
|
|
|
|
|
|
H. Fujii, S. Suehiro, H. Kumano, T. Shibata, K. Hattori, H. Hirai, and T. Aoyama Relationship between granulocyte elastase and C3a under protamine dosing in on-pump cardiac surgery Eur J Cardiothorac Surg, September 1, 2005; 28(3): 431 - 434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. Creswell, J. C. Alexander Jr., T. B. Ferguson Jr., A. Lisbon, and L. A. Fleisher Intraoperative Interventions: American College of Chest Physicians Guidelines for the Prevention and Management of Postoperative Atrial Fibrillation After Cardiac Surgery Chest, August 1, 2005; 128(2_suppl): 28S - 35S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Karamlou, J. M. Schultz, C. Silliman, C. Sandquist, J. You, I. Shen, and R. M. Ungerleider Using a Miniaturized Circuit and an Asanguineous Prime to Reduce Neutrophil-Mediated Organ Dysfunction Following Infant Cardiopulmonary Bypass Ann. Thorac. Surg., July 1, 2005; 80(1): 6 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Abdel-Rahman, F. Ozaslan, P. S. Risteski, S. Martens, A. Moritz, A. Al Daraghmeh, H. Keller, and G. Wimmer-Greinecker Initial Experience With a Minimized Extracorporeal Bypass System: Is There a Clinical Benefit? Ann. Thorac. Surg., July 1, 2005; 80(1): 238 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Thiele, P. Sick, E. Boudriot, K.-W. Diederich, R. Hambrecht, J. Niebauer, and G. Schuler Randomized comparison of intra-aortic balloon support with a percutaneous left ventricular assist device in patients with revascularized acute myocardial infarction complicated by cardiogenic shock Eur. Heart J., July 1, 2005; 26(13): 1276 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Nesher, G. Uretzky, S. Insler, P. Nataf, I. Frolkis, E. Pineau, E. Cantoni, G. Bolotin, M. Vardi, D. Pevni, et al. Thermo-wrap technology preserves normothermia better than routine thermal care in patients undergoing off-pump coronary artery bypass and is associated with lower immune response and lesser myocardial damage J. Thorac. Cardiovasc. Surg., June 1, 2005; 129(6): 1371 - 1378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Komai, Y. Naito, and Y. Okamura Dextran sulfate as a leukocyte-endothelium adhesion molecule inhibitor of lung injury in pediatric open-heart surgery Perfusion, March 1, 2005; 20(2): 77 - 82. [Abstract] [PDF]
|
|
|
|
|
|
H. Takai, K. Eishi, S. Yamachika, S. Hazama, T. Ariyoshi, and K. Nishi Demonstration and Operative Influence of Low Prime Volume Closed Pump Asian Cardiovasc Thorac Ann, March 1, 2005; 13(1): 65 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. A. Paraskevaidis, E. K. Iliodromitis, D. Vlahakos, D. P. Tsiapras, A. Nikolaidis, A. Marathias, A. Michalis, and D. Th. Kremastinos Deferoxamine infusion during coronary artery bypass grafting ameliorates lipid peroxidation and protects the myocardium against reperfusion injury: immediate and long-term significance Eur. Heart J., February 1, 2005; 26(3): 263 - 270. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. V. Sheppard, R. V. Gibbs, and D. C. Smith Does leucocyte depletion during cardiopulmonary bypass improve oxygenation indices in patients with mild lung dysfunction? Br. J. Anaesth., December 1, 2004; 93(6): 789 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hravnak, L. A. Hoffman, M. I. Saul, T. G. Zullo, J. F. Cuneo, and R. V. Pellegrini Short-Term Complications and Resource Utilization in Matched Subjects After On-Pump or Off-Pump Primary Isolated Coronary Artery Bypass Am. J. Crit. Care., November 1, 2004; 13(6): 499 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kolln, E. Spillner, J. Andra, K. Klensang, and R. Bredehorst Complement Inactivation by Recombinant Human C3 Derivatives J. Immunol., November 1, 2004; 173(9): 5540 - 5545. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. van den Goor, R. Nieuwland, A. van den Brink, W. van Oeveren, P. Rutten, J. Tijssen, and L. Eijsman Reduced complement activation during cardiopulmonary bypass does not affect the postoperative acute phase response Eur J Cardiothorac Surg, November 1, 2004; 26(5): 926 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Knobloch, A. Lichtenberg, J. Schubert, and A. Haverich Paroxysmal nocturnal hemoglobinuria - pre- and perioperative rationale during cardiac surgery using extracorporeal circulation Eur J Cardiothorac Surg, November 1, 2004; 26(5): 1058 - 1059. [Full Text] [PDF]
|
|
|
|
|
|
M. Cavaglia, S. G. Seshadri, J. E. Marchand, C. L. Ochocki, R. B. B. Mee, and P. M. Bokesch Increased Transcription Factor Expression and Permeability of the Blood Brain Barrier Associated With Cardiopulmonary Bypass in Lambs Ann. Thorac. Surg., October 1, 2004; 78(4): 1418 - 1425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Athanasiou, O. Aziz, O. Mangoush, S. Al-Ruzzeh, S. Nair, V. Malinovski, R. Casula, and B. Glenville Does off-pump coronary artery bypass reduce the incidence of post-operative atrial fibrillation? A question revisited Eur J Cardiothorac Surg, October 1, 2004; 26(4): 701 - 710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Mathew, S. K. Shernan, W. D. White, J. C.K. Fitch, J. C. Chen, L. Bell, and M. F. Newman Preliminary Report of the Effects of Complement Suppression With Pexelizumab on Neurocognitive Decline After Coronary Artery Bypass Graft Surgery Stroke, October 1, 2004; 35(10): 2335 - 2339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Scholz, A. Simon, M. Berg, A. M. Schuller, M. Hacibayramoglu, S. Margraf, A. Theisen, J. Windolf, G. Wimmer-Greinecker, and A. Moritz In vivo inhibition of neutrophil activity by a FAS (CD95) stimulating module: Arterial in-line application in a porcine cardiac surgery model J. Thorac. Cardiovasc. Surg., June 1, 2004; 127(6): 1735 - 1742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Weigang, J. Royl, A. Dencker, J. Schoellhorn, A. van de Loo, and F. Beyersdorf Results after MIDCAB and OPCAB surgeries: problems and consequences of incomplete angiographic follow-up in the mid-term course Interact CardioVasc Thorac Surg, June 1, 2004; 3(2): 302 - 308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. Verrier, S. K. Shernan, K. M. Taylor, F. Van de Werf, M. F. Newman, J. C. Chen, M. Carrier, A. Haverich, K. J. Malloy, P. X. Adams, et al. Terminal Complement Blockade With Pexelizumab During Coronary Artery Bypass Graft Surgery Requiring Cardiopulmonary Bypass: A Randomized Trial JAMA, May 19, 2004; 291(19): 2319 - 2327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. N Hoel, V. Videm, S. T Baksaas, T. E Mollnes, F. Brosstad, and J. L Svennevig Comparison of a Duraflo II-coated cardiopulmonary bypass circuit and a trillium-coated oxygenator during open-heart surgery Perfusion, May 1, 2004; 19(3): 177 - 184. [Abstract] [PDF]
|
|
|
|
|
|
T. Ikuta, H. Fujii, T. Shibata, K. Hattori, H. Hirai, H. Kumano, and S. Suehiro A new poly-2-methoxyethylacrylate-coated cardiopulmonary bypass circuit possesses superior platelet preservation and inflammatory suppression efficacy Ann. Thorac. Surg., May 1, 2004; 77(5): 1678 - 1683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Hamamoto, M. Suga, T. Nakatani, Y. Takahashi, Y. Sato, S. Inamori, T. Yagihara, and S. Kitamura Phosphodiesterase type 4 inhibitor prevents acute lung injury induced by cardiopulmonary bypass in a rat model Eur J Cardiothorac Surg, May 1, 2004; 25(5): 833 - 838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. L. Kwak, Y. J. Oh, S. M. Jung, K. J. Yoo, J. H. Lee, and Y. W. Hong Change in right ventricular function during off-pump coronary artery bypass graft surgery Eur J Cardiothorac Surg, April 1, 2004; 25(4): 572 - 577. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Verma, P. W.M. Fedak, R. D. Weisel, P. E. Szmitko, M. V. Badiwala, D. Bonneau, D. Latter, L. Errett, and Y. LeClerc Off-Pump Coronary Artery Bypass Surgery: Fundamentals for the Clinical Cardiologist Circulation, March 16, 2004; 109(10): 1206 - 1211. [Full Text] [PDF]
|
|
|
|
|
|
M Tang, Y J Gu, W J Wang, Y P Xu, and C Z Chen Effect of cardiopulmonary bypass on leukocyte activation: changes in membrane-bound elastase on neutrophils Perfusion, March 1, 2004; 19(2): 93 - 99. [Abstract] [PDF]
|
|
|
|
|
|
K. Durgut, K. Hosgor, N. Gormus, U. Ozergin, and H. Solak The cerebroprotective effects of pentoxifylline and aprotinin during cardiopulmonary bypass in dogs Perfusion, March 1, 2004; 19(2): 101 - 106. [Abstract] [PDF]
|
|
|
|
|
|
J. B. Moreno, S. Margraf, A. M Schuller, A Simon, A Moritz, and M Scholz Inhibition of neutrophil activity in cardiac surgery with cardiopulmonary bypass: a novel strategy with the leukocyte inhibition module Perfusion, January 1, 2004; 19(1): 11 - 16. [Abstract] [PDF]
|
|
|
|
|
|
K. Knobloch, A. Lichtenberg, R. G. Leyh, and J. Schubert Aortic valve replacement and coronary revascularization in paroxysmal nocturnal hemoglobinuria Interact CardioVasc Thorac Surg, December 1, 2003; 2(4): 647 - 649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yoshimura, Y. Hiramatsu, Y. Sato, S. Homma, Y. Enomoto, T. Jikuya, and Y. Sakakibara ONO-6818, a novel, potent neutrophil elastase inhibitor, reduces inflammatory mediators during simulated extracorporeal circulation Ann. Thorac. Surg., October 1, 2003; 76(4): 1234 - 1239. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Lim, R. Motalleb-Zadeh, M. Wallard, N. Misra, E. Akowuah, I. Ahmed, J. C. Halstead, F. Murphy, J. Foweraker, and S. Tsui Pyrexia after cardiac surgery: natural history and association with infection J. Thorac. Cardiovasc. Surg., October 1, 2003; 126(4): 1013 - 1017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gaudino, A. Di Castelnuovo, R. Zamparelli, F. Andreotti, F. Burzotta, L. Iacoviello, F. Glieca, F. Alessandrini, G. Nasso, M. B. Donati, et al. Genetic control of postoperative systemic inflammatory reaction and pulmonary and renal complications after coronary artery surgery J. Thorac. Cardiovasc. Surg., October 1, 2003; 126(4): 1107 - 1112. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. Scott, F. C. Seifert, P. S. A. Glass, and R. Grimson Blood Use in Patients Undergoing Coronary Artery Bypass Surgery: Impact Of Cardiopulmonary Bypass Pump, Hematocrit, Gender, Age, and Body Weight Anesth. Analg., October 1, 2003; 97(4): 958 - 963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Ngaage Off-pump coronary artery bypass grafting: the myth, the logic and the science Eur J Cardiothorac Surg, October 1, 2003; 24(4): 557 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Chong, C. R. Hampton, and E. D. Verrier Microvascular Inflammatory Response in Cardiac Surgery Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2003; 7(3): 333 - 354. [Abstract] [PDF]
|
|
|
|
|
|
P. Biglioli, A. Cannata, F. Alamanni, M. Naliato, M. Porqueddu, M. Zanobini, E. Tremoli, and A. Parolari Biological effects of off-pump vs. on-pump coronary artery surgery: focus on inflammation, hemostasis and oxidative stress Eur J Cardiothorac Surg, August 1, 2003; 24(2): 260 - 269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Gourlay and P Connolly Does cardiopulmonary bypass still represent a good investment? The biomaterials perspective Perfusion, July 1, 2003; 18(4): 225 - 231. [Abstract] [PDF]
|
|
|
|
|
|
J. J Sistino Expanding the role of perfusionists in the era of new treatment options for cardiovascular disease Perfusion, July 1, 2003; 18(4): 253 - 256. [Abstract] [PDF]
|
|
|
|
|
|
T. Aybek, P. Kessler, M. F. Khan, S. Dogan, G. Neidhart, A. Moritz, and G. Wimmer-Greinecker Operative techniques in awake coronary artery bypass grafting J. Thorac. Cardiovasc. Surg., June 1, 2003; 125(6): 1394 - 1400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Alhabash, A. Tirouvanziam, J. C. Roussel, and D. Duveau Early and 1 year angiographic evaluation of graft patency in off-pump coronary bypass surgery via sternotomy Interact CardioVasc Thorac Surg, June 1, 2003; 2(2): 149 - 153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Aybek, P. Kessler, S. Dogan, G. Neidhart, M. F. Khan, G. Wimmer-Greinecker, and A. Moritz Awake coronary artery bypass grafting: utopia or reality? Ann. Thorac. Surg., April 1, 2003; 75(4): 1165 - 1170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Costello, C. L. Backer, A. de Hoyos, H. J. Binns, and C. Mavroudis Aprotinin reduces operative closure time and blood product use after pediatric bypass Ann. Thorac. Surg., April 1, 2003; 75(4): 1261 - 1266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Risnes, T. Ueland, P. Aukrust, R. Lundblad, S. T. Baksaas, T. E. Mollnes, and J. L. Svennevig Complement activation and cytokine and chemokines release during mediastinitis Ann. Thorac. Surg., March 1, 2003; 75(3): 981 - 985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Wimmer-Greinecker and On behalf of the International Council of Emboli M Reduction of neurologic complications by intra-aortic filtration in patients undergoing combined intracardiac and CABG procedures Eur J Cardiothorac Surg, February 1, 2003; 23(2): 159 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Ascione and G.D Angelini OPCAB surgery: a voyage of discovery back to the future Eur. Heart J., January 2, 2003; 24(2): 121 - 124. [Full Text] [PDF]
|
|
|
|
|
|
D. Royston, T. Kovesi, and N. Marczin The unwanted response to cardiac surgery: Time for a reappraisal? J. Thorac. Cardiovasc. Surg., January 1, 2003; 125(1): 32 - 35. [Full Text] [PDF]
|
|
|
|
|
|
A. J de Vries, Y J. Gu, W. J Post, P. Vos, I. Stokroos, H. Lip, and W. van Oeveren Leucocyte depletion during cardiac surgery: a comparison of different filtration strategies Perfusion, January 1, 2003; 18(1): 31 - 38. [Abstract] [PDF]
|
|
|
|
|
|
R. Ascione, M. Caputo, and G. D. Angelini Off-pump coronary artery bypass grafting: not a flash in the pan Ann. Thorac. Surg., January 1, 2003; 75(1): 306 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sato, Y. Hiramatsu, S. Homma, S. Sato, M. Onizuka, and Y. Sakakibara Phosphodiesterase type 4 inhibition of activated polymorphonuclear leukocytes in a simulated extracorporeal circulation model J. Thorac. Cardiovasc. Surg., January 1, 2003; 125(1): 172 - 177. [Abstract] [Full Text]
|
|
|
|
|
|
P. Menasche and L. H. Edmunds Jr. Extracorporeal Circulation: The Inflammatory Response Card. Surg. Adult, January 1, 2003; 2(2003): 349 - 360. [Full Text]
|
|
|
|
|
|
R. Salenger, J. S. Gammie, and T. J. Vander Salm Postoperative Care of Cardiac Surgical Patients Card. Surg. Adult, January 1, 2003; 2(2003): 439 - 469. [Full Text]
|
|
|
|
|
|
M. Caputo, M. Yeatman, P. Narayan, G. Marchetto, R. Ascione, B. C. Reeves, and G. D. Angelini Effect of off-pump coronary surgery with right ventricular assist device on organ function and inflammatory response: a randomized controlled trial Ann. Thorac. Surg., December 1, 2002; 74(6): 2088 - 2095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P. Brown, M. J. Mack, A. W. Simon, S. Battaglia, L. Tarkington, S. Horner, S. D. Culler, and E. R. Becker Outcomes experience with off-pump coronary artery bypass surgery in women Ann. Thorac. Surg., December 1, 2002; 74(6): 2113 - 2119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Chen-Scarabelli Beating-Heart Coronary Artery Bypass Graft Surgery: Indications, Advantages, and Limitations Crit. Care Nurse, October 1, 2002; 22(5): 44 - 58. [Full Text] [PDF]
|
|
|
|
|
|
H.-H Sievers, C. Freund-Kaas, S. Eleftheriadis, T. Fischer, H. Kuppe, E. G. Kraatz, and J.F. M. Bechtel Lung protection during total cardiopulmonary bypass by isolated lung perfusion: preliminary results of a novel perfusion strategy Ann. Thorac. Surg., October 1, 2002; 74(4): 1167 - 1172. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. J. Gu, P. Schoen, I. Tigchelaar, B. G. Loef, T. Ebels, A. J. Rankin, and W. van Oeveren Increased neutrophil priming and sensitization before commencing cardiopulmonary bypass in cardiac surgical patients Ann. Thorac. Surg., October 1, 2002; 74(4): 1173 - 1179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Naughton and C. A. Bashour Mechanical Support After Cardiac Surgery Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2002; 6(3): 237 - 257. [Abstract] [PDF]
|
|
|
|
|
|
J. Borgermann, I. Friedrich, S. Flohe, J. Spillner, M. Majetschak, O. Kuss, A. Sablotzki, T. Feldt, J. C. Reidemeister, and F. U. Schade Tumor necrosis factor-{alpha} production in whole blood after cardiopulmonary bypass: Downregulation caused by circulating cytokine-inhibitory activities J. Thorac. Cardiovasc. Surg., September 1, 2002; 124(3): 608 - 617. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
