HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rajah, S. M. Articles by Watson, D. A. Search for Related Content PubMed PubMed Citation Articles by Rajah, S. M. Articles by Watson, D. A.

The Journal of Thoracic and Cardiovascular Surgery, Vol 90, 373-377, Copyright © 1985 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Acetylsalicylic acid and dipyridamole improve the early patency of aorta-coronary bypass grafts. A double-blind, placebo-controlled, randomized trial

SM Rajah, MC Salter, DR Donaldson, R Subba Rao, RM Boyle, JB Partridge and DA Watson

A total of 125 patients undergoing aorta-coronary bypass grafting for disabling angina were randomized to receive either 330 mg of acetylsalicylic acid (aspirin) plus 75 mg of dipyridamole three times daily or a placebo for 6 months postoperatively. In addition, all patients were given warfarin for 3 months. Repeat angiography was performed at 6 months in 103 patients. In the treatment group 95 grafts were implanted in 48 patients, of which 87 were patent (91.6% patency rate). This figure compares with 88 grafts patent out of 118 implanted in 55 patients in the placebo group (74.6% patency rate) (p less than 0.01). We conclude that antiplatelet therapy improves the early patency of saphenous vein aorta-coronary bypass grafts.

This article has been cited by other articles:

				R. C. Becker, T. W. Meade, P. B. Berger, M. Ezekowitz, C. M. O'Connor, D. A. Vorchheimer, G. H. Guyatt, D. B. Mark, and R. A. Harrington The Primary and Secondary Prevention of Coronary Artery Disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest, June 1, 2008; 133(6_suppl): 776S - 814S. [Abstract] [Full Text] [PDF]

				P. D. Stein, H. J. Schunemann, J. E. Dalen, and D. Gutterman Antithrombotic Therapy in Patients With Saphenous Vein and Internal Mammary Artery Bypass Grafts: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy Chest, September 1, 2004; 126(3_suppl): 600S - 608S. [Abstract] [Full Text] [PDF]

				E. Lim, Z. Ali, A. Ali, T. Routledge, L. Edmonds, D. G Altman, and S. Large Indirect comparison meta-analysis of aspirin therapy after coronary surgery BMJ, December 6, 2003; 327(7427): 1309. [Abstract] [Full Text] [PDF]

				T. Huynh, P. Theroux, P. Bogaty, J. Nasmith, and S. Solymoss Aspirin, Warfarin, or the Combination for Secondary Prevention of Coronary Events in Patients With Acute Coronary Syndromes and Prior Coronary Artery Bypass Surgery Circulation, June 26, 2001; 103(25): 3069 - 3074. [Abstract] [Full Text] [PDF]

				P. D. Stein, J. E. Dalen, S. Goldman, and P. Theroux Antithrombotic Therapy in Patients With Saphenous Vein and Internal Mammary Artery Bypass Grafts Chest, January 1, 2001; 119(2009): 278S - 282S. [Full Text] [PDF]

				S. S. Anand and S. Yusuf Oral Anticoagulant Therapy in Patients With Coronary Artery Disease: A Meta-analysis JAMA, December 1, 1999; 282(21): 2058 - 2067. [Abstract] [Full Text] [PDF]

				C. C. Otley, J. L. Fewkes, W. Frank, and S. M. Olbricht Complications of Cutaneous Surgery in Patients Who Are Taking Warfarin, Aspirin, or Nonsteroidal Anti-inflammatory Drugs Arch Dermatol, February 1, 1996; 132(2): 161 - 166. [Abstract] [PDF]

				S. M. Rajah, U. Nair, M. Rees, N. Saunders, D. Walker, G. Williams, A. Critchley, D. Beton, C. Campbell, R. A. Lawson, et al. Effects of antiplatelet therapy with indobufen or aspirin-dipyridamole on graft patency one year after coronary artery bypass grafting J. Thorac. Cardiovasc. Surg., April 1, 1994; 107(4): 1146 - 1153. [Abstract] [Full Text]

				Collaborative overview of randomised trials of antiplatelet therapy - II: Maintenance of vascular graft or arterial patency by antiplatelet therapy BMJ, January 15, 1994; 308(6922): 159 - 168. [Abstract] [Full Text]

				Antiplatelet Trialists Collaborative overview of randomised trials of antiplatelet therapy Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients BMJ, January 8, 1994; 308(6921): 81 - 106. [Abstract] [Full Text]

				J. B. Wong, F. A. Sonnenberg, D. N. Salem, and S. G. Pauker Myocardial Revascularization for Chronic Stable Angina: Analysis of the Role of Percutaneous Transluminal Coronary Angioplasty Based on Data Available in 1989 Ann Intern Med, December 1, 1990; 113(11): 852 - 871. [Abstract] [PDF]

				G. P. Clagett Antithrombotic Drugs and Vascular Surgery Perspectives in Vascular Surgery and Endovascular Therapy, January 1, 1990; 3(2): 79 - 102. [PDF]

				V. A. Ferraris, S. P. Ferraris, F. C. Lough, and W. R. Berry Preoperative Aspirin Ingestion Increases Operative Blood Loss after Coronary Artery Bypass Grafting Ann. Thorac. Surg., January 1, 1988; 45(1): 71 - 74. [Abstract] [PDF]

				T. N. Keltz, M. Innerfield, B. Gitler, and J. A. Cooper Dipyridamole-lnduced Myocardial Ischemia JAMA, March 20, 1987; 257(11): 1515 - 1516. [Abstract] [PDF]