| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Thoracic and Cardiovascular Surgery, Vol 91, 428-435, Copyright © 1986 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
ER Rosenkranz, F Okamoto, GD Buckberg, JM Robertson, J Vinten-Johansen and HI Bugyi
This study tests the hypothesis that aspartate enrichment of glutamate-
blood cardioplegia improves metabolic and functional recovery after
ischemic and reperfusion damage. Ischemic and reperfusion damage were
produced in 15 dogs by 45 minutes of aortic clamping at 37 degrees C and 5
minutes of blood reperfusion, before 2 more hours of aortic clamping
(simulated operation). Six received multidose blood cardioplegia at 4
degrees C. In nine others, the cardioplegic solution was infused at 37
degrees C for the first 5 minutes, followed by multidose infusions at 4
degrees C. Four received 26 mmol glutamate- enriched cardioplegic solution.
In five, the glutamate (13 mmol) cardioplegic solution was enriched with
aspartate (13 mmol). Oxygen uptake and ventricular function (stroke work
index, left atrial pressure) were measured. These data suggest aspartate
enrichment produced the highest oxygen uptake (32 +/- 4 versus 17 +/- 2
ml/100 gm for glutamate and 7 +/- 1 ml/100 gm for 4 degrees C blood
cardioplegia). Complete functional recovery occurred in
aspartate/glutamate-treated hearts (stroke work index 90% +/- 4%, left
atrial pressure 12 +/- 2 mm Hg), whereas recovery was incomplete with both
glutamate alone (stroke work index 66% +/- 14%, left atrial pressure 20 +/-
3 mm Hg) and 4 degrees C blood cardioplegia at low cardiac outputs. Eight
of 10 hearts not receiving aspartate failed at high cardiac outputs.
Aspartate enrichment of glutamate-blood cardioplegia improves recovery
after severe ischemic/reperfusion damage by improving oxidative metabolism
during cardioplegic infusion and during postischemic work.
ARTICLES
Safety of prolonged aortic clamping with blood cardioplegia. III. Aspartate enrichment of glutamate-blood cardioplegia in energy-depleted hearts after ischemic and reperfusion injury
This article has been cited by other articles:
|
|
 |
|
  Y. Toyoda, J. Thacker, R. Santos, D. Nguyen, J. Bhama, C. Bermudez, R. Kormos, B. Johnson, M. Crespo, J. Pilewski, et al. Long-Term Outcome of Lung and Heart-Lung Transplantation for Idiopathic Pulmonary Arterial Hypertension Ann. Thorac. Surg., October 1, 2008; 86(4): 1116 - 1122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Doenst, H. Bugger, M. Schwarzer, G. Faerber, M. A. Borger, and F. W. Mohr Three good reasons for heart surgeons to understand cardiac metabolism Eur. J. Cardiothorac. Surg., May 1, 2008; 33(5): 862 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Warren, C. Alexiou, R. Massey, D. Leff, S. Purkayastha, J. Kinross, A. Darzi, and T. Athanasiou The effects of various leukocyte filtration strategies in cardiac surgery Eur. J. Cardiothorac. Surg., April 1, 2007; 31(4): 665 - 676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Martin and C. Benk Blood cardioplegia MMCTS, October 9, 2006; 2006(1009): 745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Kassab, M. Kostelec, G. D. Buckberg, J. Covell, A. Sadeghi, and J. I.E. Hoffman Myocardial protection in the failing heart: II. Effect of pulsatile cardioplegic perfusion under simulated left ventricular restoration J. Thorac. Cardiovasc. Surg., October 1, 2006; 132(4): 884 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Buckberg Stroke and extra-cardiac perfusion: new vantage points in brain protection Eur. J. Cardiothorac. Surg., December 1, 2004; 26(Suppl_1): S62 - S67. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Modi, M.-S. Suleiman, B. Reeves, A. Pawade, A.J. Parry, G.D. Angelini, and M. Caputo Myocardial metabolic changes during pediatric cardiac surgery: A randomized study of 3 cardioplegic techniques J. Thorac. Cardiovasc. Surg., July 1, 2004; 128(1): 67 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Castella, G. D. Buckberg, and Z. Tan Blood cardioplegic protection in profoundly damaged hearts: role of Na+-H+ exchange inhibition during pretreatment or during controlled reperfusion supplementation Ann. Thorac. Surg., April 1, 2003; 75(4): 1238 - 1245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Martin, M. Krause, C. Benk, G. Lutter, M. Siegenthaler, and F. Beyersdorf Blood cardioplegia filtration Perfusion, January 1, 2003; 18(1_suppl): 75 - 80. [Abstract] [PDF]
|
|
|
|
|
|
R. Groom, J. Tryzelaar, R. Forest, K. Niimi, G. Cecere, D. Donegan, S. Katz, P. Weldner, R. Quinn, J. Braxton, et al. Intra-operative quality assessment of coronary artery bypass grafts Perfusion, December 1, 2001; 16(6): 511 - 518. [Abstract] [PDF]
|
|
|
|
|
|
M. D. Crittenden Intraoperative metabolic monitoring of the heart: I. Clinical assessment of coronary sinus metabolites Ann. Thorac. Surg., December 1, 2001; 72(6): S2220 - 2226. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Kronon, B. S. Allen, S. Rahman, T. Wang, N. A. Tayyab, K. S. Bolling, and M. N. Ilbawi Reducing postischemic reperfusion damage in neonates using a terminal warm substrate-enriched blood cardioplegic reperfusate Ann. Thorac. Surg., September 1, 2000; 70(3): 765 - 770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M.F. Elwatidy, M. A. Fadalah, E. A. Bukhari, K. A. Aljubair, A. Syed, A. K. Ashmeg, and M. R. Alfagih Antegrade crystalloid cardioplegia vs antegrade/retrograde cold and tepid blood cardioplegia in CABG Ann. Thorac. Surg., August 1, 1999; 68(2): 447 - 453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Penta de Peppo, P. Polisca, F. Tomai, R. De Paulis, F. Turani, E. Zupancich, L. Sommariva, P. Pasqualetti, and L. Chiariello Recovery of LV contractility in man is enhanced by preischemic administration of enflurane Ann. Thorac. Surg., July 1, 1999; 68(1): 112 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A T. Ulus, P. Gokce, E. Ozgencil, U. Yildiz, E. Ibrisim, and S F. Katircioglu Beneficial Effects of Aminophylline on Ischemia-Reperfusion in Isolated Rabbit Heart Asian Cardiovasc Thorac Ann, June 1, 1999; 7(2): 96 - 100. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Vanhanen, E. Hakanson, L. Jorfeldt, and R. Svedjeholm Intravenous Aspartate Infusion After a Coronary Operation: Effects on Myocardial Metabolism and Hemodynamic State Ann. Thorac. Surg., May 1, 1998; 65(5): 1296 - 1302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Bolling, M. Kronon, B. S. Allen, T. Wang, S. Ramon, and H. Feinberg MYOCARDIAL PROTECTION IN NORMAL AND HYPOXICALLY STRESSED NEONATAL HEARTS: THE SUPERIORITY OF BLOOD VERSUS CRYSTALLOID CARDIOPLEGIA J. Thorac. Cardiovasc. Surg., June 1, 1997; 113(6): 994 - 1005. [Abstract] [Full Text]
|
|
|
|
|
|
H. R. Ghomeshi, G. Tian, J. Ye, J. Sun, E. F. Hoffenberg, T. A. Salerno, and R. Deslauriers ASPARTATE/GLUTAMATE-ENRICHED BLOOD DOES NOT IMPROVE MYOCARDIAL ENERGY METABOLISM DURING ISCHEMIA-REPERFUSION: A 31P MAGNETIC RESONANCE SPECTROSCOPIC STUDY IN ISOLATED PIG HEARTS J. Thorac. Cardiovasc. Surg., June 1, 1997; 113(6): 1068 - 1080. [Abstract] [Full Text]
|
|
|
|
|
|
S. S. Sett, H. Tearle, and J. G. LeBlanc EFFECT OF GLUTAMATE-ASPARTATE REPERFUSION ON POSTISCHEMIC NEONATAL MYOCARDIUM J. Thorac. Cardiovasc. Surg., March 1, 1997; 113(3): 462 - 466. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Ihnken, K. Morita, G. D. Buckberg, B. Winkelmann, M. Schmitt, L. J. Ignarro, M.P. Sherman, and K. Ihnken Nitric-Oxide-Induced Reoxygenation Injury in the Cyanotic Immature Heart Is Prevented by Controlling Oxygen Content During Initial Reoxygenation Angiology, March 1, 1997; 48(3): 189 - 202. [Abstract] [PDF]
|
|
|
|
|
|
A. Mizuno, R. Baretti, G. D. Buckberg, H. H. Young, J. Vinten-Johansen, X.-L. Ma, and L. J. Ignarro ENDOTHELIAL STUNNING AND MYOCYTE RECOVERY AFTER REPERFUSION OF JEOPARDIZED MUSCLE: A ROLE OF L-ARGININE BLOOD CARDIOPLEGIA J. Thorac. Cardiovasc. Surg., February 1, 1997; 113(2): 379 - 389. [Abstract] [Full Text]
|
|
|
|
|
|
R. Svedjeholm, I. Vanhanen, E. Hakanson, P. O. Joachimsson, L. Jorfeldt, and L. Nilsson METABOLIC AND HEMODYNAMIC EFFECTS OF INTRAVENOUS GLUTAMATE INFUSION EARLY AFTER CORONARY OPERATIONS J. Thorac. Cardiovasc. Surg., December 1, 1996; 112(6): 1468 - 1477. [Abstract] [Full Text]
|
|
|
|
|
|
M. K. Reed, C. Barak, C. R. Malloy, S. P. Maniscalco, and M. E. Jessen EFFECTS OF GLUTAMATE AND ASPARTATE ON MYOCARDIAL SUBSTRATE OXIDATION DURING POTASSIUM ARREST J. Thorac. Cardiovasc. Surg., December 1, 1996; 112(6): 1651 - 1660. [Abstract] [Full Text]
|
|
|
|
|
|
G. D. Buckberg INVITED EDITORIAL ON ""EFFECTS OF GLUTAMATE AND ASPARTATE ON MYOCARDIAL SUBSTRATE OXIDATION DURING POTASSIUM ARREST"" J. Thorac. Cardiovasc. Surg., December 1, 1996; 112(6): 1661 - 1663. [Full Text]
|
|
|
|
|
|
B. S. Allen, D. Murcia-Evans, and R. S. Hartz Integrated Cardioplegia Allows Complex Valve Repairs in All Patients Ann. Thorac. Surg., July 1, 1996; 62(1): 23 - 29. [Abstract] [Full Text]
|
|
|
|
|
|
G. W. Laub, S. Muralidharan, J. Reibman, J. Fernandez, W. A. Anderson, J. Gu, C. Daloisio, L. B. McGrath, and L. J. Mulligan ESMOLOL AND PERCUTANEOUS CARDIOPULMONARY BYPASS ENHANCE MYOCARDIAL SALVAGE DURING ISCHEMIA IN A DOG MODEL J. Thorac. Cardiovasc. Surg., May 1, 1996; 111(5): 1085 - 1091. [Abstract] [Full Text]
|
|
|
|
|
|
H. C. Alhan, H. Karabulut, R. Tosun, F. Karakoc, I. Okar, E. Demiray, S. Tarcan, and B. Yigiter Intermittent Aortic Cross-Clamping and Cold Crystalloid Cardioplegia for Low-Risk Coronary Patients Ann. Thorac. Surg., March 1, 1996; 61(3): 834 - 839. [Abstract] [Full Text]
|
|
|
|
|
|
E. R. Rosenkranz Substrate Enhancement of Cardioplegic Solution: Experimental Studies and Clinical Evaluation Ann. Thorac. Surg., September 1, 1995; 60(3): 797 - 800. [Abstract] [Full Text]
|
|
|
|
|
|
G. D. Buckberg Update on Current Techniques of Myocardial Protection Ann. Thorac. Surg., September 1, 1995; 60(3): 805 - 814. [Abstract] [Full Text]
|
|
|
|
|
|
H. L. Lazar, X. Zhang, S. Rivers, S. Bernard, and R. J. Shemin Limiting Ischemic Myocardial Damage Using Glucose-Insulin-Potassium Solutions Ann. Thorac. Surg., August 1, 1995; 60(2): 411 - 416. [Abstract] [Full Text]
|
|
|
|
|
|
T. Ko, H. Otani, H. Imamura, K. Omori, and C. Inagaki Role of sodium pump activity in warm induction of cardioplegia combined with reperfusion of oxygenated cardioplegic solution J. Thorac. Cardiovasc. Surg., July 1, 1995; 110(1): 103 - 110. [Abstract] [Full Text]
|
|
|
|
|
|
O. I. Pisarenko, F. L. Rosenfeldt, L. Langley, R. A. J. Conyers, and S. M. Richards Differing Protection With Aspartate and Glutamate Cardioplegia in the Isolated Rat Heart Ann. Thorac. Surg., June 1, 1995; 59(6): 1541 - 1548. [Abstract] [Full Text]
|
|
|
|
|
|
B. S. Allen, J. W. Winkelmann, H. Hanafy, R. S. Hartz, K. S. Bolling, J. Ham, and S. Feinstein Retrograde cardioplegia does not adequately perfuse the right ventricle J. Thorac. Cardiovasc. Surg., June 1, 1995; 109(6): 1116 - 1126. [Abstract] [Full Text]
|
|
|
|
|
|
A. M. Calafiore, G. Teodori, A. Mezzetti, G. Bosco, A. M. Verna, G. Di Giammarco, and D. Lapenna Intermittent Antegrade Warm Blood Cardioplegia Ann. Thorac. Surg., February 1, 1995; 59(2): 398 - 402. [Abstract] [Full Text]
|
|
|
|
|
|
T. Asai, E. A. Grossi, M. LeBoutillier III, M. A. Parish, F. G. Baumann, F. C. Spencer, S. B. Colvin, and A. C. Galloway Resuscitative retrograde blood cardioplegiaAre amino acids or continuous warm techniques necessary? J. Thorac. Cardiovasc. Surg., February 1, 1995; 109(2): 242 - 248. [Abstract] [Full Text]
|
|
|
|
|
|
W. R. Chitwood Jr and C. L. Wixon Update in Myocardial Protection Ann. Thorac. Surg., January 1, 1995; 59(1): 253 - 254. [Full Text]
|
|
|
|
|
|
G. D. Buckberg Normothermic blood cardioplegiaAlternative or adjunct? J. Thorac. Cardiovasc. Surg., March 1, 1994; 107(3): 860 - 867. [Abstract] [Full Text]
|
|
|
|
|
|
J. M. Pearl, H. Laks, D. C. Drinkwater, T. J. Sorensen, P. Chang, A. S. Aharon, R. E. Byrns, and L. J. Ignarro Loss of endothelium-dependent vasodilatation and nitric oxide release after myocardial protection with University of Wisconsin solution J. Thorac. Cardiovasc. Surg., January 1, 1994; 107(1): 257 - 264. [Abstract] [Full Text]
|
|
|
|
|
|
C. Munsch Review article : Blood cardioplegia Perfusion, October 1, 1991; 6(4): 245 - 252. [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
