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The Journal of Thoracic and Cardiovascular Surgery, Vol 93, 45-55, Copyright © 1987 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
DE Hansen, PD Cahill, GC Derby and DC Miller
The relative importance of the anterior and posterior mitral chordae
tendineae to global left ventricular performance, independent of load, was
determined by sequentially measuring the slope of the left ventricular peak
isovolumetric pressure-volume relation in a canine model with the chordae
of both, either, and neither mitral leaflet(s) intact. The order in which
the chordae were severed was randomly assigned. Compared to baseline values
(both chordae intact), severing the chordae of the anterior leaflet
(posterior leaflet chordae intact) reduced the slope of the pressure-volume
relation by 27% (p = 0.005) in 10 dogs; the slope decreased by an
additional 16% (p = 0.017) when the posterior chordae were subsequently
severed in this group. In 10 dogs randomized to the reverse order, the
slope of the pressure-volume relation decreased by 17% (p = 0.021) after
the posterior chordae were severed (anterior leaflet chordae intact); an
additional 24% decrease in the slope (p = 0.001) occurred when the chordae
of the anterior leaflet were subsequently severed in this group. The
chordae of the anterior and posterior mitral leaflets have an additive, but
statistically indistinguishable (p = 0.140), influence upon global left
ventricular systolic performance; however, the contribution of the anterior
chordae tends to be more important. Thus preservation of the anterior
mitral leaflet and its chordal attachments to the papillary muscles during
mitral valve replacement may have an equal or greater impact upon
postoperative left ventricular function than mitral valve replacement with
preservation of the posterior chordae; however, severing either the
anterior or posterior chordae appears to be detrimental.
ARTICLES
Relative contributions of the anterior and posterior mitral chordae tendineae to canine global left ventricular systolic function [published erratum appears in J Thorac Cardiovasc Surg 1987 May;93(5):793]
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