HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Smith, E. E. Articles by Kirklin, J. W. Search for Related Content PubMed PubMed Citation Articles by Smith, E. E. Articles by Kirklin, J. W.

The Journal of Thoracic and Cardiovascular Surgery, Vol 94, 225-233, Copyright © 1987 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Microvascular permeability after cardiopulmonary bypass. An experimental study

EE Smith, DC Naftel, EH Blackstone and JW Kirklin

Microvascular permeability is presumed to increase during cardiopulmonary bypass, but this has not been directly demonstrated. Method: Therefore, a controlled experimental study was performed in dogs in which the permeability ratio of the small intestinal microvasculature was determined. Shortly after 120 minutes of cardiopulmonary bypass (experimental group, n = 7) or a sham procedure (control group, n = 7), the superior mesenteric venous pressure was raised in a stepwise fashion until the intestinal lymph/plasma protein concentration stabilized at a minimum value. Data: Minimal lymph/plasma concentration ratio (permeability ratio) of the total proteins and each of six protein fractions was greater in dogs that had been on bypass than in control dogs (p = 0.01 for total proteins and less than 0.05 for five of the fractions). The variability in this regard was large in both groups, and in some animals subjected to bypass the permeability ratio was more than twice the maximum value for the control group. The increase in permeability ratio was greater for large molecules. Inferences: Cardiopulmonary bypass results in a variable increase in microvascular permeability. This results primarily from an increase in the size of large pores in the microvascular barrier.

This article has been cited by other articles:

				J. W. Hammon Extracorporeal Circulation: The Response of Humoral and Cellular Elements of Blood to Extracorporeal Circulation Card. Surg. Adult, January 1, 2008; 3(2008): 370 - 389. [Full Text]

				J. W. Hammon Extracorporeal Circulation: Organ Damage Card. Surg. Adult, January 1, 2008; 3(2008): 389 - 414. [Full Text]

				T. L. Butler, C. G. Au, B. Yang, J. R. Egan, Y. M. Tan, E. C. Hardeman, K. N. North, A. S. Verkman, and D. S. Winlaw Cardiac aquaporin expression in humans, rats, and mice Am J Physiol Heart Circ Physiol, August 1, 2006; 291(2): H705 - H713. [Abstract] [Full Text] [PDF]

				E. A. Hessel II Abdominal Organ Injury After Cardiac Surgery Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2004; 8(3): 243 - 263. [Abstract] [PDF]

				Y. Hamada, K. Kawachi, N. Tsunooka, Y. Nakamura, S. Takano, and H. Imagawa Capillary Leakage in Cardiac Surgery with Cardiopulmonary Bypass Asian Cardiovasc Thorac Ann, September 1, 2004; 12(3): 193 - 197. [Abstract] [Full Text] [PDF]

				P. Menasche and L. H. Edmunds Jr. Extracorporeal Circulation: The Inflammatory Response Card. Surg. Adult, January 1, 2003; 2(2003): 349 - 360. [Full Text]

				J. W. Hammon Jr. and L. H. Edmunds Jr. Extracorporeal Circulation: Organ Damage Card. Surg. Adult, January 1, 2003; 2(2003): 361 - 388. [Full Text]

				C. Joffs, H. R. Gunasinghe, M. M. Multani, B. H. Dorman, J. M. Kratz, A. J. Crumbley III, F. A. Crawford Jr, and F. G. Spinale Cardiopulmonary bypass induces the synthesis and release of matrix metalloproteinases Ann. Thorac. Surg., May 1, 2001; 71(5): 1518 - 1523. [Abstract] [Full Text] [PDF]

				C. S. Cox Jr, S. J. Allen, H. Sauer, and J. Frederick EFFECTS OF SELECTIN-SIALYL LEWISX BLOCKADE ON MESENTERIC MICROVASCULAR PERMEABILITY ASSOCIATED WITH CARDIOPULMONARY BYPASS J. Thorac. Cardiovasc. Surg., June 1, 2000; 119(6): 1255 - 1261. [Abstract] [Full Text] [PDF]

				C. S. Cox Jr., M. Brennan, and S. J. Allen Impact of hetastarch on the intestinal microvascular barrier during ECLS J Appl Physiol, April 1, 2000; 88(4): 1374 - 1380. [Abstract] [Full Text] [PDF]

				R. Munoz, P. C. Laussen, G. Palacio, L. Zienko, G. Piercey, and D. L. Wessel CHANGES IN WHOLE BLOOD LACTATE LEVELS DURING CARDIOPULMONARY BYPASS FOR SURGERY FOR CONGENITAL CARDIAC DISEASE: AN EARLY INDICATOR OF MORBIDITY AND MORTALITY J. Thorac. Cardiovasc. Surg., January 1, 2000; 119(1): 155 - 162. [Abstract] [Full Text] [PDF]

				A. P. Goldman, R. E. Delius, J. E. Deanfield, M. R. de Leval, P. E. Sigston, and D. J. Macrae Nitric Oxide Might Reduce the Need for Extracorporeal Support in Children With Critical Postoperative Pulmonary Hypertension Ann. Thorac. Surg., September 1, 1996; 62(3): 750 - 755. [Abstract] [Full Text]

				V. M. Reddy, J. R. Liddicoat, J. R. Klein, D. B. McElhinney, R. K. Wampler, and F. L. Hanley Fetal Cardiac Bypass Using an In-Line Axial Flow Pump to Minimize Extracorporeal Surface and Avoid Priming Volume Ann. Thorac. Surg., August 1, 1996; 62(2): 393 - 400. [Abstract] [Full Text]

				G. Wernovsky, D. Wypij, R. A. Jonas, J. E. Mayer Jr, F. L. Hanley, P. R. Hickey, A. Z. Walsh, A. C. Chang, A. R. Castaneda, J. W. Newburger, et al. Postoperative Course and Hemodynamic Profile After the Arterial Switch Operation in Neonates and Infants : A Comparison of Low-Flow Cardiopulmonary Bypass and Circulatory Arrest Circulation, October 15, 1995; 92(8): 2226 - 2235. [Abstract] [Full Text]

				A. P. Goldman, R. E. Delius, J. E. Deanfield, and D. J. Macrae Nitric Oxide Is Superior to Prostacyclin for Pulmonary Hypertension After Cardiac Operations Ann. Thorac. Surg., August 1, 1995; 60(2): 300 - 305. [Abstract] [Full Text]

				P. M. Kilbridge, J. E. Mayer, J. W. Newburger, P. R. Hickey, A. Z. Walsh, and E. J. Neufeld Induction of intercellular adhesion molecule-1 and E-selectin mRNA in heart and skeletal muscle of pediatric patients undergoing cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., May 1, 1994; 107(5): 1183 - 1192. [Abstract] [Full Text]

				D. Johnson, D. Thomson, T. Hurst, K. Prasad, T. Wilson, F. Murphy, A. Saxena, and I. Mayers Neutrophil-mediated acute lung injury after extracorporeal perfusion J. Thorac. Cardiovasc. Surg., May 1, 1994; 107(5): 1193 - 1202. [Abstract] [Full Text]

				H. Komai and S. G Haworth The effect of cardiopulmonary bypass on the lung: the injured pulmonary vascular endothelium Perfusion, January 1, 1993; 8(1): 55 - 62. [PDF]