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The Journal of Thoracic and Cardiovascular Surgery, Vol 94, 367-374, Copyright © 1987 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
DJ Wheatley, J Fisher, IJ Reece, T Spyt and P Breeze
A number of centers have recorded a significant incidence of primary tissue
failure with the standard Ionescu-Shiley pericardial valve. In most cases
severe regurgitation was caused by leaflet tears adjacent to the edge of
the cloth-covered stent. Our early clinical experience (up to 4 years'
follow-up) with two new pericardial valves (Ionescu-Shiley low-profile and
Hancock pericardial valves) has shown that primary tissue failure also
occurs in these new valves. In vitro accelerated fatigue studies on seven
of these valves (size 29 mm) showed that in vitro premature leaflet failure
was caused by abrasion of the leaflet on the cloth-covering at the edge of
the stent. Clinically, endothelialization and host tissue ingrowth on the
cloth and the leaflets at the edge of the frame greatly reduced the amount
of abrasion and the incidence of tissue failure. In seven of the eight
explanted valves studied, leaflet tears occurred at the top of the stent
posts where there was less endothelialization and tissue ingrowth, close to
the points where sutures pass through the leaflets. It is likely that both
abrasion and stress concentration around these sutures contributed to the
tissue failures in the clinical valves.
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Primary tissue failure in pericardial heart valves
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