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The Journal of Thoracic and Cardiovascular Surgery, Vol 94, 419-429, Copyright © 1987 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
SL Hilbert, VJ Ferrans, Y Tomita, EE Eidbo and M Jones
Morphologic, chemical, and hemodynamic studies were made of eight prototype
polyurethane trileaflet cardiac valve prostheses that had been implanted in
juvenile sheep for 17 to 21 weeks in the mitral position. Calcification of
the polyurethane leaflet surfaces was the principal finding. Quantitative
chemical analyses revealed calcium values with a mean of 42.7 +/- 21 mg/gm
dry weight of leaflet. Morphologically, two distinct types of calcification
were observed: One was associated with the polyurethane surface or the
interface between the leaflet surface and microthrombi or fibrous sheaths;
the other was characterized by calcification associated with degenerated
cells within thrombotic material and the fibrous sheath. These morphologic
findings were in accord with the results of hemodynamic performance studies
indicating that these heart valve prostheses had become both stenotic and
regurgitant.
ARTICLES
Evaluation of explanted polyurethane trileaflet cardiac valve prostheses
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