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The Journal of Thoracic and Cardiovascular Surgery, Vol 95, 70-74, Copyright © 1988 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
GA Patterson, JD Cooper, JH Dark and MT Jones
We have previously demonstrated the technical feasibility of an en bloc
double lung transplantation in acute canine experiments. We have now
conducted survival experiments in cynomolgus monkeys. Profound hypothermia
and circulatory arrest were used to avoid the need for cardiopulmonary
bypass in these very small animals. Because of the complexities of this
technique, few long-term survivals resulted, but these experiments did
confirm excellent lung function and satisfactory tracheal healing. On the
basis of these experiments, we have performed our first clinical double
lung transplantation on a 42-year-old woman with end-stage emphysema caused
by alpha 2-antitrypsin deficiency. The patient has returned to normal
activities with excellent lung function.
ARTICLES
Experimental and clinical double lung transplantation
Division of Thoracic Surgery, Toronto General Hospital, Ontario, Canada.
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