HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sawa, Y. Articles by Kawashima, Y. Search for Related Content PubMed PubMed Citation Articles by Sawa, Y. Articles by Kawashima, Y.

The Journal of Thoracic and Cardiovascular Surgery, Vol 97, 229-234, Copyright © 1989 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Comparison of single dose versus multiple dose crystalloid cardioplegia in neonate. Experimental study with neonatal rabbits from birth to 2 days of age

Y Sawa, H Matsuda, Y Shimazaki, K Kadoba, S Onishi, T Nakada and Y Kawashima
First Department of Surgery, Osaka University Medical School, Japan.

Thirty-five isolated hearts from newborn rabbits (aged birth to 2 days) were subjected to 120 minutes of ischemia at 15 degrees C with high potassium crystalloid cardioplegia. They were divided into four groups according to the method of cardioplegic administration: group C (preischemic control, n = 9), group S (single dose, n = 10), group M-1 (multiple dose, infused every 40 minutes, n = 7), and group M-2 (multiple dose, infused every 20 minutes, n = 9). After 30 minutes of reperfusion, the heart rate, coronary flow, creatine kinase release, percent water content, and myocardial ultrastructural scores for mitochondrial damage and intracellular edema were compared among the four groups. All of these parameters except coronary flow were significantly poorer in group M-2 than in groups C and S (p less than 0.05). The mitochondrial damage and intracellular edema scores were significantly poorer in group M-1 than in group C (p less than 0.05). No significant differences in these two scores were seen between group S and group C and between group S and group M-1. These results indicate that the single dose method of administering crystalloid cardioplegia may provide better myocardial protection than the multiple dose method in the neonate.

This article has been cited by other articles:

				K. G. Warner, M. G. Sheahan, S. M. Arebi, A. Banerjee, J. M. Deiss-Shrem, and K. R. Khabbaz Proper timing of blood cardioplegia in infant lambs: superiority of a multiple-dose regimen Ann. Thorac. Surg., March 1, 2001; 71(3): 872 - 876. [Abstract] [Full Text] [PDF]

				M. E. Jessen, A. S. Abd-Elfattah, and A. S. Wechsler Neonatal Myocardial Oxygen Consumption During Ventricular Fibrillation, Hypothermia, and Potassium Arrest Ann. Thorac. Surg., January 1, 1996; 61(1): 82 - 87. [Abstract] [Full Text]

				Y. Sawa, S. Nakano, Y. Shimazaki, M. Nishimura, T. Kuratani, and H. Matsuda Myocardial protective effect and its mechanism of leukocyte-depleted reperfusion in neonatal rabbit hearts Ann. Thorac. Surg., November 1, 1994; 58(5): 1386 - 1390. [Abstract] [PDF]

				L. J. Kohman and L. J. Veit Single-dose versus multidose cardioplegia in neonatal hearts J. Thorac. Cardiovasc. Surg., June 1, 1994; 107(6): 1512 - 1518. [Abstract] [Full Text]

				C. Chang-Chun, H. Matsuda, Y. Sawa, M. Kaneko, N. Sakagoshi, M. Nishimura, T. Kuratani, A. Amemiya, and Y. Kawashima Effect of a cyclic adenosine monophosphate phosphodiesterase inhibitor, DN-9693, on myocardial reperfusion injury Ann. Thorac. Surg., September 1, 1991; 52(3): 495 - 499. [Abstract] [PDF]