HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Illes, R. W. Articles by Levitsky, S. Search for Related Content PubMed PubMed Citation Articles by Illes, R. W. Articles by Levitsky, S.

The Journal of Thoracic and Cardiovascular Surgery, Vol 98, 1051-1056, Copyright © 1989 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

The efficacy of blood cardioplegia is not due to oxygen delivery

RW Illes, NA Silverman, IB Krukenkamp, RD Yusen, DD Chausow and S Levitsky
Department of Surgery, University of Illinois, College of Medicine, Chicago.

Twenty-seven canine hearts instrumented with ultrasonic dimension crystals underwent simultaneous determination of stroke work and myocardial oxygen consumption during incremental volume loading on right heart bypass before and 30 minutes after 2 hours of cardioplegic arrest at 10 degrees C. Three cardioplegic solutions were used: Hematocrit values were 17.0% (group I), 8.2% (group II), and 0% (group III). In all groups the slope of the linear stroke work versus end- diastolic volume relationship, a measure of contractility, was unchanged after ischemic arrest. However, the myocardial oxygen consumption for basal metabolism was increased an average of 25.5% after arrest with plasma (group III). Since the plasma concentration in all three groups was identical, and the oxygen available to the hearts during ischemia was the same in groups II and III, the efficacy of blood-based cardioplegic solutions cannot be attributed to a plasma component or to the greater oxygen-carrying capacity of the red blood cell. Future studies should attempt to identify the salutory entity of the red cell responsible for preservation of myocardial oxygen consumption efficiency.

This article has been cited by other articles:

				K. A. Eagle, R. A. Guyton, R. Davidoff, G. A. Ewy, J. Fonger, T. J. Gardner, J. P. Gott, H. C. Herrmann, R. A. Marlow, W. C. Nugent, et al. ACC/AHA guidelines for coronary artery bypass graft surgery: A report of the American College of Cardiology/ American Heart Association task force on Practice Guidelines (Committee to revise the 1991 Guidelines for Coronary Artery Bypass Graft Surgery) J. Am. Coll. Cardiol., October 1, 1999; 34(4): 1262 - 1347. [Full Text] [PDF]

				I. Birdi, M. B. Izzat, A. J. Bryan, and G. D. Angelini Normothermic Techniques During Open Heart Operations Ann. Thorac. Surg., May 1, 1996; 61(5): 1573 - 1580. [Abstract] [Full Text]

				W. L. Holman, W. V. A. Vicente, R. D. Spruell, S. B. Digerness, and A. D. Pacifico Effect of hemoglobin concentration on oxyhemoglobin dissociation during hypothermic blood cardioplegic arrest J. Thorac. Cardiovasc. Surg., October 1, 1994; 108(4): 664 - 671. [Abstract] [Full Text]

				H. B. Barner Blood cardioplegia: A review and comparison with crystalloid cardioplegia Ann. Thorac. Surg., December 1, 1991; 52(6): 1354 - 1367. [Abstract] [PDF]

				C. Munsch Review article : Blood cardioplegia Perfusion, October 1, 1991; 6(4): 245 - 252. [PDF]

				J. Vinten-Johansen, J. S. Julian, H. Yokoyama, W. E. Johnston, T. D. Smith, D. S. McGee, and A. R. Cordell Efficacy of myocardial protection with hypothermic blood cardioplegia depends on oxygen Ann. Thorac. Surg., October 1, 1991; 52(4): 939 - 948. [Abstract] [PDF]