| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Thoracic and Cardiovascular Surgery, Vol 99, 469-474, Copyright © 1990 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
SF Bolling, LE Bies, EL Bove and KP Gallagher
The objective of this study was to determine if augmentation of myocardial
adenosine levels during global ischemia improves functional recovery after
reperfusion. Isolated adult rabbit hearts were subjected to 120 minutes of
mildly hypothermic ischemia (34 degrees C) with modified St. Thomas'
Hospital cardioplegic solution used to provide myocardial protection.
Myocardial adenosine levels were augmented during ischemia by providing
exogenous adenosine in the cardioplegic solution or by inhibiting adenosine
degradation with 2-deoxycoformycin, a noncompetitive inhibitor of adenosine
deaminase. Four groups of hearts were studied: (1) control (n =
23)--cardioplegia alone; (2) adenosine group (n = 10)--adenosine 200
mumol/L added to the cardioplegic solution; (3) 2-deoxycoformycin group (n
= 8)--2- deoxycoformycin 1 mumol/L added to the cardioplegic solution; and
(4) a combined adenosine/deoxycoformycin group (n = 10). Recovery of
developed pressure 45 minutes after reperfusion in the control group
averaged only 38% +/- 4% of baseline values. Significantly better recovery
was evident in the adenosine (66% +/- 7%), deoxycoformycin (59% +/- 2%),
and adenosine/deoxycoformycin (75% +/- 2%) groups. The slope of the
relationship between end-diastolic pressure and volume was used as an index
of diastolic stiffness. The slope averaged 85 +/- 2 mm Hg/ml in the control
group 45 minutes after reperfusion, significantly higher than that in the
adenosine (31 +/- 6), deoxycoformycin (75 +/- 5), and
adenosine/deoxycoformycin (58 +/- 5) groups; this suggests better diastolic
function in the adenosine-augmented groups. During ischemia, adenosine
levels were significantly elevated in the adenosine- augmented groups,
whereas adenosine triphosphate decreased equally in all four groups, which
indicates that augmenting myocardial adenosine had no effect on depletion
of adenosine triphosphate during ischemia. After reperfusion, adenosine
triphosphate levels were depressed in the control group but increased in
the other groups above baseline values, which suggests that improvement in
functional recovery was due to accelerated repletion of adenine nucleotide
stores in the adenosine- augmented groups.
ARTICLES
Augmenting intracellular adenosine improves myocardial recovery
Thoracic Surgery Research Laboratory, University of Michigan Medical School, Ann Arbor.
This article has been cited by other articles:
|
|
 |
|
  J. Peart, G. Paul Matherne, R. J. Cerniway, and J. P. Headrick Cardioprotection with adenosine metabolism inhibitors in ischemic-reperfused mouse heart Cardiovasc Res, October 1, 2001; 52(1): 120 - 129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. G. Fogelson, S. I. Nawas, and W. R. Law MECHANISMS OF MYOCARDIAL PROTECTION BY ADENOSINE-SUPPLEMENTED CARDIOPLEGIC SOLUTION: MYOFILAMENT AND METABOLIC RESPONSES J. Thorac. Cardiovasc. Surg., March 1, 2000; 119(3): 601 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Cohen, M. A. Borger, R. D. Weisel, and V. Rao Intraoperative myocardial protection: current trends and future perspectives Ann. Thorac. Surg., November 1, 1999; 68(5): 1995 - 2001. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Jayawant and R. J. Damiano Jr The superiority of pinacidil over adenosine cardioplegia in blood-perfused isolated hearts Ann. Thorac. Surg., October 1, 1998; 66(4): 1329 - 1335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Rohs, K. S. Kilgore, A. J. Georges, and S. F. Bolling Postischemic Function and Protein Kinase C Signal Transduction Ann. Thorac. Surg., June 1, 1998; 65(6): 1680 - 1684. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Barankiewicz, A. M. Danks, E. Abushanab, L. Makings, T. Wiemann, R. A. Wallis, P. V. P. Pragnacharyulu, A. Fox, and P. J. Marangos Regulation of Adenosine Concentration and Cytoprotective Effects of Novel Reversible Adenosine Deaminase Inhibitors J. Pharmacol. Exp. Ther., December 1, 1997; 283(3): 1230 - 1238. [Abstract] [Full Text]
|
|
|
|
|
|
O. Katayama, S. J. M. Ledingham, M. Amrani, R. T. Smolenski, D. R. Lachno, J. Jayakumar, and M. H. Yacoub Functional and Metabolic Effects of Adenosine in Cardioplegia: Role of Temperature and Concentration Ann. Thorac. Surg., February 1, 1997; 63(2): 449 - 454. [Abstract] [Full Text]
|
|
|
|
|
|
R. D. Lasley and R. M. Mentzer Jr Protective effects of adenosine in the reversibly injured heart Ann. Thorac. Surg., September 1, 1995; 60(3): 843 - 846. [Abstract] [PDF]
|
|
|
|
|
|
S. E. Fremes, J. Zhang, R. D. Furukawa, D. A. G. Mickle, and R. D. Weisel ADENOSINE PRETREATMENT FOR PROLONGED CARDIAC STORAGEAn evaluation with St. Thomas' Hospital and University of Wisconsin solutions J. Thorac. Cardiovasc. Surg., August 1, 1995; 110(2): 293 - 301. [Abstract] [Full Text]
|
|
|
|
|
|
S. E. Fremes, R. D. Furukawa, J. Zhang, R.-K. Li, L. C. Tumiati, R. D. Weisel, and D. A. G. Mickle Cardiac storage with University of Wisconsin solution and a nucleoside-transport blocker Ann. Thorac. Surg., May 1, 1995; 59(5): 1127 - 1133. [Abstract] [PDF]
|
|
|
|
|
|
D. A. Hudspeth, K. Nakanishi, J. Vinten-Johansen, Z.-Q. Zhao, D. S. McGee, M. W. Williams, and J. W. Hammon Jr Adenosine in blood cardioplegia prevents postischemic dysfunction in ischemically injured hearts Ann. Thorac. Surg., December 1, 1994; 58(6): 1637 - 1644. [Abstract] [PDF]
|
|
|
|
|
|
D. A. Hudspeth, M. W. Williams, Z.-Q. Zhao, H. Sato, K. Nakanishi, D. S. McGee, J. W. Hammon Jr, J. Vinten-Johansen, and D. G. L. Van Wylen Pentostatin-augmented interstitial adenosine prevents postcardioplegia injury in damaged hearts Ann. Thorac. Surg., September 1, 1994; 58(3): 719 - 727. [Abstract] [PDF]
|
|
|
|
|
|
A. K. Pridjian, E. L. Bove, S. F. Bolling, K. F. Childs, K. M. Brosamer, and F. M. Lupinetti Developmental differences in myocardial protection in response to 5'-nucleotidase inhibition J. Thorac. Cardiovasc. Surg., February 1, 1994; 107(2): 520 - 526. [Abstract] [Full Text]
|
|
|
|
|
|
S. F. Bolling, M. A. Groh, A. M. Mattson, R. A. Grinage, and K. P. Gallagher Acadesine (AICA-riboside) improves postischemic cardiac recovery Ann. Thorac. Surg., July 1, 1992; 54(1): 93 - 98. [Abstract] [PDF]
|
|
|
|
|
|
T. L. Demmy, J. A. Magovern, R. L. Kao, and G. J. Magovern Resuscitation of injured myocardium with adenosine and biventricular assist Ann. Thorac. Surg., November 1, 1991; 52(5): 1044 - 1051. [Abstract] [PDF]
|
|
|
|
|
|
S. E. Fremes, R.-K. Li, R. D. Weisel, D. A. G. Mickle, R. D. Furukawa, and L. C. Tumiati The limits of cardiac preservation with University of Wisconsin solution Ann. Thorac. Surg., October 1, 1991; 52(4): 1021 - 1025. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
