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The Journal of Thoracic and Cardiovascular Surgery, Vol 99, 622-630, Copyright © 1990 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
A Lessana, C Carbone, M Romano, E Palsky, YH Quan, M Escorsin, B Jegier, A Ruffenach, G Lutfalla and F Aime
From January 1975 to June 1988, 275 patients underwent mitral valve repair
for mitral regurgitation, pure (148 patients) or associated with mitral
stenosis (127 patients). Patients with pure mitral stenosis were excluded
from this study. The cause of mitral regurgitation was rheumatic in 180
patients (aged 28.6 +/- 1.2 years, mean +/- standard error of the mean) and
degenerative in 84 patients (aged 54.7 +/- 1.5 years). Fifty-nine percent
of the patients were in New York Heart Association classes III and IV
before the operation. Intraoperative assessment of the mitral valve led us
to identify four major mechanisms of mitral regurgitation: (1) restriction
of leaflet motion by fibrosis (group I, 63 patients); (2) enhancement of
leaflet motion by leaflet and chordal extension and prolapse (group II, 139
patients), (3) combination of both (group III, 64 patients); and (4)
isolated dilatation of the anulus (group IV, 10 patients). One hundred
sixty-one patients had isolated mitral disease and 114 had associated
aortic or tricuspid valve disease, or both. The hospital mortality rate was
4.0%. Follow-up was 96% complete and totaled 1247.47 patient-years. At 13
years' follow-up, the survival rate was 93.0% +/- 6.8% in group I, 90.0%
+/- 6.0% in group II, and 96.6% +/- 4.6% in group III. Freedom from
reoperation was 78.1% +/- 21.0%, 83.2% +/- 18.9%, and 79.6% +/- 16.2%,
respectively. Freedom from embolism was 94.7% for the whole series. In
patients with isolated mitral valve repair, the cumulative morbidity was
significantly higher in groups I (6.3 +/- 2.0%/pt-yr) and III 6.3% +/-
1.7%/pt-yr) than in group II (2.5% +/- 0.9%/pt-yr, p less than 0.05).
Multivariate analysis identified age and associated tricuspid valve disease
as significant predictors of reoperation (p less than 0.01 for both
factors). These results suggest that conservative surgery should be used
with caution in group I and III patients. In contrast, indications for
mitral valve repair should be extended in group II patients. This
observation has important clinical implications since, in Western
countries, valve prolapse tends to be a major cause of mitral
regurgitation.
ARTICLES
Mitral valve repair: results and the decision-making process in reconstruction. Report of 275 cases
Le Service de Chirurgie Cardio-vasculaire CHPA La Roseraie, Aubervilliers, France.
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