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The Journal of Thoracic and Cardiovascular Surgery, Vol 99, 798-808, Copyright © 1990 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association
PD Skillington, RH Davies, AJ Luff, JD Williams, KD Dawkins, N Conway, RK Lamb, DF Shore, JL Monro and JK Ross
A total of 101 patients (mean age 64.9 years) underwent surgical correction
of postinfarction ventricular septal defect at this institution over a
15-year period (1973 to 1988). The overall early mortality rate was 20.8%,
although the most recent experience with 36 patients (January 1987 to
October 1988) has seen this decline to 11.1%. Factors found to influence
early death significantly, when analyzed univariately, were as follows: (1)
site of infarction (anterior 12.1%, inferior 32.6%, p = 0.02); (2) time
interval between infarction and operation (less than 1 week 34.1%, greater
than 1 week 10.5%, p = 0.008); (3) cardiogenic shock (present 38.1%, absent
8.5%, p = 0.001). Nonsignificant variables included preoperative renal
function, age, and concomitant coronary artery bypass, although older age
(greater than 65 years) became significant when examined in a multivariate
fashion. Of the 80 hospital survivors, eight were subsequently found to
have a recurrent or residual defect necessitating reoperation, with
survival in seven. Late follow-up is 99% complete and reveals an actuarial
survival rate for 100 patients of 71.1% at 5 years (95% confidence interval
60.6 to 80.0), and 40.0% at 10 years (95% confidence interval 21.7 to
58.4). A significant recent change in policy of not using coronary
angiography in patients with a ventricular septal defect caused by anterior
wall infarction has not resulted in any increase in either the early
mortality or in the late prevalence of angina. The functional status of 38
surviving patients has been analyzed by a graded treadmill exercise
protocol, whereas left ventricular functional assessment was by nuclear
scan with additional information on mitral valve function by
echocardiogram. Color Doppler flow mapping has been used to determine the
presence of a residual defect. Most late survivors have limited exercise
tolerance related to both cardiac and noncardiac factors. Left ventricular
function is moderately impaired (mean ejection fraction = 0.39). However,
many patients are elderly and have adapted to their residual symptoms
without significant changes in life-style.
ARTICLES
Surgical treatment for infarct-related ventricular septal defects. Improved early results combined with analysis of late functional status
Wessex Cardiothoracic Centre, Southampton General Hospital, England.
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