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The Journal of Thoracic and Cardiovascular Surgery, Vol 99, 1059-1062, Copyright © 1990 by The American Association for Thoracic Surgery and The Western Thoracic Surgical Association

ARTICLES

Chronic rejection in single-lung transplantation manifested by obliterative bronchiolitis

J LoCicero 3d, PG Robinson and M Fisher
Department of Surgery, Northwestern University Medical School, Chicago, Ill. 60611-3008.

Chronic rejection of the lung in patients with heart-lung transplants has most often been associated with the development of obliterative bronchiolitis. Previously only one patient receiving a single-lung transplant suffered from the development of this problem. We describe a patient whose obliterative bronchiolitis developed 9 months after single-lung transplantation. Progressive deterioration occurred until his death from obliterative bronchiolitis at 21 months after transplantation. The functional and histologic changes are described and the possible mechanisms discussed.


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