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J Thorac Cardiovasc Surg 2001;121:0176-0177
© 2001 The American Association for Thoracic Surgery

Brief Communications

Ondansetron hydrochloride for the treatment of delirium after coronary artery surgery

Osman Bayindir, MD, Mustafa Güden, MD, Belhhan Akpinar, MD, Ilhan SanisoGlu, Ertan SaGbas, Sisli-Istanbul Turkey

From the Departments of Anesthesia and Cardiovascular Surgery, Kadir Has University Medical Faculty, Florence Nightingale Hospital, Sisli-Istanbul, Turkey.

Received for publication May 25, 1999. Accepted for publication May 22, 2000. Address for reprints: Belhhan Akpinar, MD, Florence Nightingale Hospital, Department of Cardiovascular Surgery, No. 290, Sisli-Istanbul, Turkey 80220 (E-mail: belh@turk. net).

Delirium remains the most common psychiatric disorder seen early after cardiac operations, with an incidence of 13% to 70%. It is characterized by reduced levels of consciousness, perceptual disturbances (eg, hallucinations), a disturbance in the sleep-wake cycle, and disturbed psychomotor activity.Go Go 1,2 The serotonergic system, which has been implicated in the development of anxiety disorders, is affected by cardiopulmonary bypass (CPB) along with many other systems and may be one of the contributing factors causing delirium. The purpose of this study was to determine whether ondansetron, a 5HT3 receptor antagonist, could be effective in treating this disorder.

Methods
After the approval of the ethical commission and institutional review board, informed consent was obtained from family members of 35 patients in whom delirium developed in the intensive care unit after coronary artery surgery. Patients with previous psychiatric disorders were excluded. Every effort was made to correct any metabolic abnormality, such as hypoxia, low cardiac output, and electrolyte disturbance before evaluation, that could cause this disorder. Before the operation, patients were premedicated . . . [Full Text of this Article]






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