HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Richard D. Weisel Terrence M. Yau Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Weisel, R. D. Articles by Yau, T. M. Search for Related Content PubMed PubMed Citation Articles by Weisel, R. D. Articles by Yau, T. M. Related Collections Molecular biology Related Article

J Thorac Cardiovasc Surg 2001;121:835-836
© 2001 The American Association for Thoracic Surgery

Editorials

Cell transplantation comes of age

From the Division of Cardiovascular Surgery, The Toronto Hospital, Toronto, Ontario, Canada.

Received for publication Feb 7, 2001. Accepted for publication Feb 9, 2001. Address for reprints: Richard D. Weisel, MD, FRCS, Division of Cardiovascular Surgery, The Toronto Hospital, 200 Elizabeth St, EN 14-215, Toronto M5G 2C4, Ontario, Canada (E-mail: Richard.Weisel@uhn.on.ca).

For related article, see p. 871.

The results of the first clinical experience with cell transplantation were reported to the American Heart Association in November 2000 by Menasche and associates ¹ of Paris. A 72-year-old man who had a transmural myocardial infarction with an ejection fraction of 21% received skeletal myoblasts implanted into the infarct region at the time of coronary bypass surgery. Five months later, he had recovered from the operation, and perfusion and function of the infarct region had improved, perhaps related to the cell transplantation. This initial case report provides hope that the damage from an extensive myocardial infarction may be reversed. Coronary bypass surgery is frequently inadequate to restore function in patients who have few viable surviving myocytes in the infarct region. Cell transplantation offers the promise of restoring function in these unfortunate patients. ^2-4 However, the era of cell transplantation has only begun. Major questions remain. What type of cell is appropriate for autotransplantation? When should these cells be delivered and by what route? What is the efficacy of cell transplantation relative to other medical and surgical treatments? What outcome . . . [Full Text of this Article]

Related Article

Cellular therapy reverses myocardial dysfunction

C. Rajnoch, J.-C. Chachques, A. Berrebi, P. Bruneval, M.-O. Benoit, and A. Carpentier
J. Thorac. Cardiovasc. Surg. 2001 121: 871-878. [Abstract] [Full Text] [PDF]

This article has been cited by other articles:

				S. L. Hendry II, K. E.A. van der Bogt, A. Y. Sheikh, T. Arai, S. J. Dylla, M. Drukker, M. V. McConnell, I. Kutschka, G. Hoyt, F. Cao, et al. Multimodal evaluation of in vivo magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells. J. Thorac. Cardiovasc. Surg., October 1, 2008; 136(4): 1028 - 1037.e1. [Abstract] [Full Text] [PDF]

				T. Kanamori, G. Watanabe, T. Yasuda, H. Nagamine, H. Kamiya, and Y. Koshida Hybrid Surgical Angiogenesis: Omentopexy Can Enhance Myocardial Angiogenesis Induced by Cell Therapy Ann. Thorac. Surg., January 1, 2006; 81(1): 160 - 167. [Abstract] [Full Text] [PDF]

				T. Yasuda, R. D. Weisel, C. Kiani, D. A.G. Mickle, M. Maganti, and R.-K. Li Quantitative analysis of survival of transplanted smooth muscle cells with real-time polymerase chain reaction J. Thorac. Cardiovasc. Surg., April 1, 2005; 129(4): 904 - 911. [Abstract] [Full Text] [PDF]

				T. Fujii, T. M. Yau, R. D. Weisel, N. Ohno, D. A. G. Mickle, N. Shiono, T. Ozawa, K. Matsubayashi, and R.-K. Li Cell transplantation to prevent heart failure: a comparison of cell types Ann. Thorac. Surg., December 1, 2003; 76(6): 2062 - 2070. [Abstract] [Full Text] [PDF]

				S. Ghostine, C. Carrion, L. C. G. Souza, P. Richard, P. Bruneval, J.-T. Vilquin, B. Pouzet, K. Schwartz, P. Menasche, and A. A. Hagege Long-Term Efficacy of Myoblast Transplantation on Regional Structure and Function After Myocardial Infarction Circulation, September 24, 2002; 106(12_suppl_1): I-131 - I-136. [Abstract] [Full Text] [PDF]

				R. C. Gorman and J. H. Gorman III Cellular myoplasty: What are we really trying to achieve? J. Thorac. Cardiovasc. Surg., March 1, 2002; 123(3): 582 - 583. [Full Text] [PDF]