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J Thorac Cardiovasc Surg 2001;122:405
© 2001 The American Association for Thoracic Surgery

Letters to the Editor

Aprotinin administration in the pericardial cavity does not prevent platelet activation

R. Clive Landis, Kenneth M. Taylor

Imperial College School of Medicine, Hammersmith Hospital, London W12 0NN, United Kingdom

To the Editor:

To better understand the hemostatic and platelet-preserving properties of aprotinin and to address the continuing controversy whether aprotinin may be prothrombotic when given to patients undergoing cardiopulmonary bypass, one must elucidate its mechanism of action on platelets in greater detail. The article by Maquelin and associatesGo 1 provides clinical support for a subtle mechanism . . . [Full Text of this Article]




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R. C. Landis
Aprotinin: Antithrombotic and Vasoactive Mechanisms of Action
Seminars in Cardiothoracic and Vascular Anesthesia, December 1, 2002; 6(4): 307 - 312.
[Abstract] [PDF]


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