JTCS Medtronic Endurant
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Niimi, M.
Right arrow Articles by Hamano, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Niimi, M.
Right arrow Articles by Hamano, K.
Related Collections
Right arrow Molecular biology
Right arrow Transplantation - heart

J Thorac Cardiovasc Surg 2001;122:629-630
© 2001 The American Association for Thoracic Surgery

Brief Communications

Indefinite survival of fully allogeneic cardiac grafts induced by antigen delivery through the alimentary tract

Masanori Niimi, MD, DPhila, Yoshifumi Ikeda, MDa, Shigenao Kan, MDa, Nozomu Shirasugi, MDa, Kimikazu Hamano, MDb, Tokyo, Yamaguchi, Japan

From the First Department of Surgery, Teikyo University School of Medicine, Tokyo,a and the First Department of Surgery, Yamaguchi University School of Medicine, Yamaguchi, Japan.b

Received for publication Jan 18, 2001. Accepted for publication Feb 6, 2001. Address for reprints: Masanori Niimi, MD, DPhil, First Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, Japan 173-8605 (E-mail: mniimi@med.teikyo-u.ac.jp).

Oral administration can induce unresponsiveness to protein antigens.Go 1 We have already shown that oral delivery of donor splenocytes induces prolonged survival of allogeneic or xenogeneic grafts when delivered with a nondepleting anti-CD4 monoclonal antibody (anti-CD4).Go Go 2,3 Intravenous injection of a single major histocompatibility complex (MHC) molecule has been shown to induce prolongation of fully MHC-mismatched grafts.Go 4 This phenomenon can be explained by the linked suppression,Go Go 4,5 in which tolerance to strain (AxB)F1 is also established when recipients become tolerant to strain A. Therefore, we have examined whether a single donor MHC antigen or soluble ovalbumin (OVA) could induce survival of fully MHC-mismatched cardiac grafts when delivered into the alimentary tract with anti-CD4.

Mice (8-12 weeks of age) were purchased from Sankyo (Tokyo, Japan) and housed in conventional facilities of the Biomedical Services Unit, Teikyo Hospital, Tokyo, and used in accordance with the Animal Care Guidelines . . . [Full Text of this Article]




This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
O. Aramaki, N. Shirasugi, Y. Akiyama, Y. Ikeda, S. Yabuki, M. Shimazu, M. Kitajima, and M. Niimi
Prolonged survival of fully allogeneic cardiac grafts in naive mice and those with sensitization induced by antigen delivery through the respiratory tract
J. Thorac. Cardiovasc. Surg., September 1, 2003; 126(3): 853 - 854.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2001 by The American Association for Thoracic Surgery.