HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chiu, R. C.-J. Search for Related Content PubMed PubMed Citation Articles by Chiu, R. C.-J. Related Collections Molecular biology Related Article

J Thorac Cardiovasc Surg 2001;122:851-852
© 2001 The American Association for Thoracic Surgery

Editorials

Therapeutic cardiac angiogenesis and myogenesis: The promises and challenges on a new frontier

From McGill University, Montreal, Quebec, Canada.

Received for publication June 8, 2001. Accepted for publication June 27, 2001. Address for reprints: Ray Chu-Jeng Chiu, MD, PhD, Department of Surgery, Montreal General Hospital, McGill University, 1650 Cedar Ave, C9-169, Montreal, PQ H3G 1A4, Canada.

See related article on page 963.

Myocardial circulatory insufficiency, cardiomyocyte necrosis, and apoptosis play important roles in many pathologic conditions of the heart. Therapeutic approaches aimed at promoting angiogenesis and growing new heart muscle fibers, currently undergoing intensive investigation and early clinical trials, therefore hold considerable promise for the future. Genes encoding angiogenic factors and angiogenic growth factor proteins, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor, are being delivered to the target tissue to induce growth of new blood vessels. For myogenesis, various progenitor and stem cells are being assessed as donor cells for implantation into the ventricular wall of injured hearts. Phase I and II clinical trials have already been undertaken for myocardial angiogenesis. Clinical studies into myogenesis have been recently initiated with implantation of autologous skeletal myoblasts into myocardial scar tissue. Although the results of phase I safety studies so far are promising, the establishment of efficacy requires rigorous phase II and III studies yet to come.

Cardiac myogenesis and angiogenesis represents a paradigm shift in our therapeutic approach, from substitution to regeneration . . . [Full Text of this Article]

Related Article

Angiogenesis by endothelial cell transplantation

Eung-Joong Kim, Ren-Ke Li, Richard D. Weisel, Donald A.G. Mickle, Zhi-Qiang Jia, Shinji Tomita, Tetsuro Sakai, and Terrence M. Yau
J. Thorac. Cardiovasc. Surg. 2001 122: 963-971. [Abstract] [Full Text] [PDF]

This article has been cited by other articles:

				A. Jacquier, C. B. Higgins, A. J. Martin, L. Do, D. Saloner, and M. Saeed Injection of Adeno-associated Viral Vector Encoding Vascular Endothelial Growth Factor Gene in Infarcted Swine Myocardium: MR Measurements of Left Ventricular Function and Strain Radiology, October 1, 2007; 245(1): 196 - 205. [Abstract] [Full Text] [PDF]

				D. J. MacDonald, J. Luo, T. Saito, M. Duong, P.-L. Bernier, R. C.J. Chiu, and D. Shum-Tim Persistence of marrow stromal cells implanted into acutely infarcted myocardium: Observations in a xenotransplant model J. Thorac. Cardiovasc. Surg., October 1, 2005; 130(4): 1114 - 1121. [Abstract] [Full Text] [PDF]

				J. C Chachques, C. Salanson-Lajos, P. Lajos, A. Shafy, A. Alshamry, and A. Carpentier Cellular Cardiomyoplasty for Myocardial Regeneration Asian Cardiovasc Thorac Ann, September 1, 2005; 13(3): 287 - 296. [Abstract] [Full Text] [PDF]

				J. C. Chachques, F. Duarte, B. Cattadori, A. Shafy, N. Lila, G. Chatellier, J.-N. Fabiani, and A. F. Carpentier Angiogenic growth factors and/or cellular therapy for myocardial regeneration: A comparative study J. Thorac. Cardiovasc. Surg., August 1, 2004; 128(2): 245 - 253. [Abstract] [Full Text] [PDF]

				J. C. Chachques, C. Acar, J. Herreros, J. C. Trainini, F. Prosper, N. D'Attellis, J.-N. Fabiani, and A. F. Carpentier Cellular cardiomyoplasty: clinical application Ann. Thorac. Surg., March 1, 2004; 77(3): 1121 - 1130. [Abstract] [Full Text] [PDF]

				R. C.-J. Chiu Reply to the Editor J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 2117 - 2117. [Full Text] [PDF]

				B. Bittira, J.-Q. Kuang, A. Al-Khaldi, D. Shum-Tim, and R. C.-J. Chiu In vitro preprogramming of marrow stromal cells for myocardial regeneration Ann. Thorac. Surg., October 1, 2002; 74(4): 1154 - 1160. [Abstract] [Full Text] [PDF]