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J Thorac Cardiovasc Surg 2002;123:395-396
© 2002 The American Association for Thoracic Surgery

Letters to the Editor

Reply

C. Dean Kurth, MD, Margaret Priestley, MD

Brain Research Laboratory
Department of Anesthesiology and Critical Care Medicine
The Children's Hospital of Philadelphia
Department of Anesthesia and Pediatrics
University of Pennsylvania School of Medicine
Philadelphia, PA 19104

Reply to the Editor:

We thank Miyamoto and MiyamotoGo 1 and Wong for their comments on pH-stat versus alpha-stat blood gas management during deep hypothermic cardiopulmonary bypass (CPB). The central question, "Which is better?," has been debated for many years.Go 2
The purpose of our study was to characterize neurologic injury in a piglet model of infant cardiac surgery using deep hypothermic CPB and total circulatory arrest (DHCA) with alpha-stat blood gas management strategy.Go 3 Miyamoto and MiyamotoGo 4 suggest that the neuronal injury resulted from the alpha-stat CPB management and not DHCA. Their rationale is that deep hypothermia and alkalosis each increase . . . [Full Text of this Article]






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