JTCS KCI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Carmelo A. Milano
Mark F. Newman
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ti, L. K.
Right arrow Articles by Mathew, J. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ti, L. K.
Right arrow Articles by Mathew, J. P.
Related Collections
Right arrow Cerebral protection
Right arrow Coronary disease
Right arrow Extracorporeal circulation

J Thorac Cardiovasc Surg 2003;125:211-213
© 2003 The American Association for Thoracic Surgery

Brief Communications

Apolipoprotein E4 increases aortic atheroma burden in cardiac surgical patients

Lian K. Ti, MMed, G. Burkhard Mackensen, MD, Hilary P. Grocott, MD, FRCPC, Daniel T. Laskowitz, MD, Barbara G. Phillips-Bute, PhD, Carmelo A. Milano, MD, Andrew K. Hilton, MB, BS, FANZCA, Mark F. Newman, MD, Joseph P. Mathew, MD the Neurologic Outcome Research Group, Durham, NC

From the Divisions of Cardiothoracic Anesthesiology and Critical Care, Cardiovascular and Thoracic Surgery, and Neurology, Departments of Anesthesiology, Surgery, and Medicine, Duke University Medical Center, Durham, NC.

Supported in part by grants from National Institutes of Health (NIH) grant 1R01HL54316, Clinical Research Centers Program NIH MO1-RR-30, and American Heart Association Grant-In-Aid 95010970.

Received for publication Sept 3, 2001. Accepted for publication May 22, 2002. Address for reprints: Joseph P. Mathew, MD, Box 3094, Duke University Medical Center, Durham, NC 27710 (E-mail: mathe014@mc.duke.edu).

The first 20% of the full text of this article appears below.

The increasing numbers of elderly patients undergoing cardiac surgery emphasizes the importance of identifying risk factors associated with adverse neurologic outcomes. Although the apolipoprotein {epsilon}4 allele (APOE*E4) has been identified as a risk factor,Go 1 how its presence increases neurologic risk remains uncertain. Apolipoprotein E (ApoE) plays a key role in lipoprotein metabolism and has an important influence on the pathophysiology of atherosclerosis. ApoE's 3 major alleles (APOE*E2, APOE*E3, and APOE*E4) result in differing susceptibility to dyslipidemia, atherosclerosis, and coronary heart disease. Therefore we sought to determine whether the APOE*E4 allele influences aortic atheroma burden in patients undergoing cardiac surgery.

Patients and methods

With institutional review board approval, a comprehensive transesophageal echocardiography examination was performed in 128 patients undergoing coronary artery bypass grafting surgery. For analysis, a videotaped frame displaying the most diseased area in each aortic segment was digitized. By tracing the outline of the atheroma, the area subtended by the atheroma was estimated (area of plaque). Similarly, the area of visualized aorta in the ascending aorta and aortic arch . . . [Full Text of this Article]




This article has been cited by other articles:


Home page
 StrokeHome page
S. Sen, A. Hinderliter, P. K. Sen, J. Simmons, V. A. LeGrys, J. Beck, S. Offenbacher, K. Moss, and S. M. Oppenheimer
Association of Leukocyte Count With Progression of Aortic Atheroma in Stroke/Transient Ischemic Attack Patients
Stroke, November 1, 2007; 38(11): 2900 - 2905.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
M. V. Podgoreanu and D. A. Schwinn
New Paradigms in Cardiovascular Medicine: Emerging Technologies and Practices: Perioperative Genomics
J. Am. Coll. Cardiol., December 6, 2005; 46(11): 1965 - 1977.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S. Bar-Yosef, M. Anders, G. B. Mackensen, L. K. Ti, J. P. Mathew, B. Phillips-Bute, R. H. Messier, H. P. Grocott, and the Neurological Outcome Research Group and CARE I
Aortic Atheroma Burden and Cognitive Dysfunction After Coronary Artery Bypass Graft Surgery
Ann. Thorac. Surg., November 1, 2004; 78(5): 1556 - 1562.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
G. B. Mackensen, L. K. Ti, B. G. Phillips-Bute, J. P. Mathew, M. F. Newman, H. P. Grocott, and the Neurologic Outcome Research Group
Cerebral embolization during cardiac surgery: impact of aortic atheroma burden
Br. J. Anaesth., November 1, 2003; 91(5): 656 - 661.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2003 by The American Association for Thoracic Surgery.