J Thorac Cardiovasc Surg 2003;125:413
© 2003 The American Association for Thoracic Surgery
From the University Hospital Graz, Department of Cardiac Surgery, Clinical Immunology, and Jean Dausset Laboratory, Graz, Austria.
Received for publication June 24, 2002. Accepted for publication July 10, 2002. Address for reprints: Peter J. Oberwalder, MD, University Hospital Graz, Cardiac Surgery, Auenbruggerplatz 29, Graz A-8036, Austria (E-mail: firstname.lastname@example.org).
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The most frequent causes of aortic dissection are medial degenerative disease and hypertension. Inflammation and immunopathologic conditions are rare and generally of a single origin. We report here on an unusual case of combined immunopathologic conditions in which simultaneous autoantibodies to nuclear factors, glomerular basement membranes, and neutrophils in accordance with concomitant systemic lupus erythematosus, Wegner disease, and Goodpasture syndrome combined to cause spontaneous acute aortic dissection.
A 43-year-old Caucasian man had a sudden
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