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J Thorac Cardiovasc Surg 2003;125:419-420
© 2003 The American Association for Thoracic Surgery

Brief Communications

Successful clinical application of tissue-engineered graft for extracardiac Fontan operation

From the Department of Cardiovascular Surgery, Heart Institute of Japan, Tokyo Women's Medical University, Tokyo, Japan.

Received for publication Feb 22, 2002. Accepted for publication July 23, 2002. Address for reprints: Yuji Naito, MD, Department of Cardiovascular Surgery, Heart Institute of Japan, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjyuku-ku, Tokyo, 162-8666, Japan (E-mail: ujinaito@aol.com).

The first 20% of the full text of this article appears below.

Currently satisfactory clinical results are observed with the extracardiac Fontan operation (ECFO); however, some issues associated with graft materials must be addressed, such as infection, thrombogenicity, and the lack of growth potential. ¹ We report here the case of a patient with occlusion of a graft implanted at initial operation and successfully underwent reoperative ECFO with a tissue-engineered graft.

Clinical summary

A 12-year-old boy had the diagnoses of polysplenia, complete atrioventricular septal defect, small left ventricle, common atrium, bilateral superior vena cava, and hemiazygous connection. A modified Blalock-Taussig shunt and ECFO with a Hemashield graft (Boston Scientific Corporation, Meadox Division, Boston, Mass) were performed at the ages of 9 and 11 years, respectively. The patient had general fatigue 7 months after ECFO. Catheterization demonstrated occlusion of the extracardiac graft. The clinical application of tissue engineering in this patient was approved by the ethical committee at Tokyo Women's Medical University, and the patient's parents were thoroughly informed and consented to the procedure. Graft replacement with a tissue-engineered . . . [Full Text of this Article]

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