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J Thorac Cardiovasc Surg 2003;125:428-429
© 2003 The American Association for Thoracic Surgery

Brief Communications

Preoperative chemotherapy is essential for conservative surgery of Askin tumors

G. Veronesi, MDa, L. Spaggiari, PhD, MDa, T. De Pas, MDb, P. G. Solli, MDa, F. De Braud, MDb, G. P. Catalano, MDc, G. Curigliano, MDb, F. Leo, MDa, U. Pastorino, MDa Milan, Italy

From the Thoracic Surgery Division,a Medical Oncology Division,b and Division of Radiotherapy,c European Institute of Oncology, Milan, Italy.

Received for publication June 26, 2002. Accepted for publication July 15, 2002. Address for reprints: Giulia Veronesi, MD, Department of Thoracic Surgery, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy (E-mail: giulia.veronesi@ieo.it).

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  		Dr Veronesi

 
A skin tumors are highly malignant thoracopulmonary tumors mainly occurring in children and adolescents. An aggressive multimodal approach (chemotherapy, surgery and radiotherapy) is the common treatment.Go Go 1,2 Takanami and associatesGo 3 recently reported on 2 long-surviving patients with Askin tumors first treated by surgery. They suggested that the best treatment schedule was surgery followed by chemotherapy, with or without radiotherapy, highlighting the issue of the best timing of chemotherapy in this disease. In our opinion many reasons justify the use of chemotherapy in a preoperative setting, including a safer and simpler surgery and the possibility to use information about tumor chemosensitivity to plan postoperative chemotherapy and radiotherapy. On this basis we treated Askin tumor with a multimodal approach that included induction chemotherapy. Here we present our favorable results with this schedule of treatments and briefly review salient literature data.

Clinical summary

Table 1 summarizes the clinical characteristics and outcomes of 5 patients with Askin tumor treated from 1998 to 2002. Patient 1 had been treated surgically elsewhere for "undifferentiated lung . . . [Full Text of this Article]






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