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J Thorac Cardiovasc Surg 2003;125:441-442
© 2003 The American Association for Thoracic Surgery

Letters to the Editor

Angiogenesis by means of endothelial cell transplantation

Valeri Chekanov, MD, PhDa, Nicholas Kipshidze, MD, PhDb

Milwaukee Heart Institute, Aurora/Sinai Medical Center, Milwaukee, Wisa, Lenox Hill Heart & Vascular Institute, Cardiovascular Research Foundation, Lenox Hill Hospital, New York, NYb

The first 20% of the full text of this article appears below.

To the Editor:

In their article, "Angiogenesis by Endothelial Cell Transplantation," Kim and associatesGo 1 present results of a novel and intriguing approach to angiogenic therapy. Their preliminary report that endothelial cell transplantation into a myocardial scar accelerates angiogenesis suggests a promising alternative to angiogenic gene or protein therapy. About the same time that their article was published, weGo 2 presented similar results before the American Heart Association at our annual scientific session (Anaheim, Calif) in November 2001.

Interestingly, we created our model of ischemic cardiomyopathy by placing an ameroid constrictor on the branch of the circumflex artery in 12 adult sheep.

In our experiment, 4 weeks after constriction, we randomly assigned 3 groups (4 animals per group) to transpericardial injection (3 . . . [Full Text of this Article]






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