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J Thorac Cardiovasc Surg 2003;125:1176
© 2003 The American Association for Thoracic Surgery

Letters to the Editor

Reply

A. C. Anyanwu, A. J. Murday

Glasgow Royal Infirmary, Glasgow, United Kingdom

The first 20% of the full text of this article appears below.

Reply to the Editor:

We appreciate the comments of Ouwens and colleagues regarding our article on economic evaluation of lung transplantation. These comments highlight a major limitation of any economic study, which is the reliance on assumptions. Economic studies of therapies that have long-term benefits necessarily make predictions of future events. Because the future is always unknown, assumptions have to be imposed to allow modeling of data into the future. Methods used for modeling data vary from study to study. For this reason most economic studies include sensitivity analyses that examine the impact of alternative assumptions on the study conclusions.

Ouwens and colleagues propose two alternative approaches to examining the benefits of lung transplantation—assessing lifetime benefits and imposing a fictitious "transplant date" for the waiting list survival. Although it is true that the benefits of transplantation . . . [Full Text of this Article]






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