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J Thorac Cardiovasc Surg 2003;126:853-854
© 2003 The American Association for Thoracic Surgery

Brief communications

Prolonged survival of fully allogeneic cardiac grafts in naive mice and those with sensitization induced by antigen delivery through the respiratory tract

Osamu Aramaki, MDa, Nozomu Shirasugi, MDb, Yosinobu Akiyama, MDb, Yoshifumi Ikeda, MDb, Shiho Yabuki, MDb, Motohide Shimazu, MDc, Masaki Kitajima, MDc, Masanori Niimi, MD, PhDb,*

a Department of Surgery, Nihon University, Tokyo, Japan
b Department of Surgery, Teikyo University, Tokyo, Japan
c Department of Surgery, Keio University, Tokyo, Japan

Received for publication March 29, 2002; accepted for publication January 14, 2003.

* Address for reprints: Masanori Niimi, MD, PhD, Department of Surgery, Teikyo University, 2-11-1 Kaga, Itabashi-ku, Tokyo, Japan 173-8605
mniimi@med.teikyo-u.ac.jp

The first 20% of the full text of this article appears below.

Nonresponsiveness to protein antigen induced by administration of the antigen through the alimentary or respiratory tract is well known as mucosal tolerance.1,2 We previously reported in this Journal that donor splenocytes delivered orally induce prolonged survival of fully allogeneic cardiac grafts and generate regulatory cells when delivered with a nondepleting anti-CD4 monoclonal antibody.3 Therefore, in this study we examined whether intratracheal delivery of alloantigen could induce prolonged survival of fully mismatched allogeneic cardiac grafts and regulatory cells.

Methods and results

Mice were purchased from Sankyo (Sankyo Co, Ltd, Tokyo, Japan) and housed in conventional facilities of the Biomedical Services Unit at Teikyo Hospital and used between 8 and 12 weeks old in accordance with the Animal Care Guidelines of Teikyo University. Mouse hearts were transplanted into the abdomens of recipients by microsurgical technique.4

Naive CBA (H2k) mice rejected fully allogeneic C57BL/10 (H2b) cardiac grafts with a median survival of 12 days (group 1; Table . . . [Full Text of this Article]






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