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J Thorac Cardiovasc Surg 2003;126:1222-1223
© 2003 The American Association for Thoracic Surgery
Brief communication |
a Departments of Anesthesia and Pharmacology and Therapeutics, Centre for Anesthesia and Analgesia, University of British Columbia, Vancouver, British Columbia, Canada
Received for publication October 3, 2002; accepted for publication March 25, 2003.
* Address for reprints: Dr David M. Ansley, University of British Columbia, Department of Anesthesiology, Room 3200, 3rd Floor JPP, 910 West 10th Ave, Vancouver, BC, Canada V5Z 4E3
daansley@interchange.ubc.ca
| The first 20% of the full text of this article appears below. |
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Low cardiac output syndrome (LCOS) adversely affects 6% to 25% of patients following cardiac surgery.1,2 Identifying factors associated with the risk of LCOS is integral to the development of new strategies to address this clinical problem. 15-F2t–isoprostane is a novel biologically active marker of lipid peroxidation and a potent vasoconstrictor3 known to induce ventricular dysfunction following experimental ischemia-reperfusion.4 Description of 15-F2t–isoprostane generation during cardiac surgery is limited, and the clinical relevance of its release and metabolism is unknown. We wanted to determine if a relationship exists between 15-F2t–isoprostane generation and early myocardial function following warm heart surgery.
Methods
Following ethics board approval and informed consent, 30 patients scheduled for coronary artery bypass grafting (CABG; n = 24) or combined valve replacement/CABG (n = 6) procedures utilizing normothermic (34°-37°C) cardiopulmonary bypass (CPB) and warm antegrade intermittent blood/crystalloid (8:1) cardioplegia were enrolled. Cardiac index (CI) was determined intraoperatively and the first 6 postoperative hours using a pulmonary artery catheter in 26 of 30 patients.
Central venous blood was sampled at baseline, at 30 minutes of
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