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J Thorac Cardiovasc Surg 2003;126:2116
© 2003 The American Association for Thoracic Surgery

Letter to the editor

Coagulation, fibrinolysis, and cell activation in patients and in shed mediastinal blood during coronary artery bypass grafting with a new heparin-coated surface

Christophe Baufreton, MD, PhD, Jean Louis de Brux, MD

Department of Cardiac Surgery, University Hospital of Angers, Angers, France

The first 20% of the full text of this article appears below.

To the Editor:

Johnell and colleagues1 recently reported the improved biocompatibility of a new heparin-coated surface. They also presented results after modifications of the anticoagulation protocol. They concluded that a low dose of systemic heparin might not be sufficient to maintain the antithrombotic activity and that a high dose resulted in increased blood activation.

The design of the study merits discussion; otherwise, the conclusion might be misunderstood. In particular, the reduction of anticoagulation, even combined with a thromboresistant extracorporeal circuit, might appear detrimental for patients undergoing cardiopulmonary bypass (CPB). The basis for a safe low anticoagulation protocol in combination with . . . [Full Text of this Article]


Related Article

Reply to the Editor
Ray C.-J. Chiu
J. Thorac. Cardiovasc. Surg. 2003 126: 2117. [Extract] [Full Text] [PDF]





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