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J Thorac Cardiovasc Surg 2003;126:2117
© 2003 The American Association for Thoracic Surgery

Letter to the editor

Reply to the Editor

Ray C.-J. Chiu, MD, PhD

Senior author, McGill University, Montreal, Quebec, Canada

The first 20% of the full text of this article appears below.

Dr Taheri made an important point in his comment, which we probably should have discussed in our article. However, first I, on behalf of my coauthors, wish to clarify that we did not inject "isogenic myofibril grafts," which would represent a differentiated anatomic unit of a muscle tissue. Instead, we transplanted either skeletal myoblasts, which are immature progenitor cells, or marrow stromal cells, which contain a pluripotent cell population. Such immature cells are able to migrate and self-assemble with preexisting supracellular structure, as we reported.

The hypothesis we postulated to explain the mechanism of this phenomenon should indeed predict that those donor cells, if implanted as an . . . [Full Text of this Article]


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