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J Thorac Cardiovasc Surg 2004;127:947-948
© 2004 The American Association for Thoracic Surgery

Editorial

Value of intraoperative pleural lavage in staging non–small cell lung cancer

Thomas A. D'Amico, MDa,*

a Duke University Medical Center, Durham, NC, USA

Received for publication December 1, 2003; accepted for publication December 12, 2003.

* Address for reprints: Thomas A. D'Amico, MD, Associate Professor of Surgery, Duke University Medical Center, Box 3496, Durham, NC 27710, USA
damic001@mc.duke.edu

The first 20% of the full text of this article appears below.


See related article on page 1113.

 

The use of adjunctive staging techniques in patients with potentially resectable non–small cell lung cancer (NSCLC) will improve survival in two ways, by selecting patients for whom surgery would be futile and by selecting patients for whom induction or adjuvant therapy could improve survival. Various biologic staging parameters have been applied to the primary tumor,1 lymph nodes,2 bone marrow,3 and serum (Brooks and colleagues, unpublished data) with demonstrated effective stratification in terms of survival and risk of recurrence. Furthermore, analysis of molecular characteristics of the tumor may stratify patients according to response to chemotherapy.4 The strategy of pleural lavage cytologic study may accomplish one, both, or neither of these objectives, depending on how it is applied.

The efficacy of pleural lavage cytologic examination was investigated by Lim and colleagues5 in a series of 292 patients who underwent thoracotomy for lung cancer. In this series, 13 (4.5%) of 292 of patients were found to have . . . [Full Text of this Article]


Related Article

Intraoperative pleural lavage cytology is an independent prognostic indicator for staging non–small cell lung cancer
Eric Lim, Ayyaz Ali, Panagiotis Theodorou, Andrew G. Nicholson, George Ladas, and Peter Goldstraw
J. Thorac. Cardiovasc. Surg. 2004 127: 1113-1118. [Abstract] [Full Text] [PDF]





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