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J Thorac Cardiovasc Surg 2004;127:1858
© 2004 The American Association for Thoracic Surgery

Letter to the editor

Reply to the Editor

Richard A. Jonas, MDa, Jane W. Newburger, MD, MPHa, David C. Bellinger, PhD, MSca

a Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA

The first 20% of the full text of this article appears below.

We thank Dr Corno for his suggestion that normothermic high-flow cardiopulmonary bypass would be likely to improve neurodevelopmental outcome relative to circulatory arrest or hypothermic reduced flow bypass, the two techniques that we studied. We agree with Dr Corno that many perfusion variables may influence late developmental outcome, and we recognize that few of these have been studied in detail. The Boston Circulatory Arrest Study, the subject of our recent report, was designed in 1987. Since that time, our laboratory studies have led . . . [Full Text of this Article]






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