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J Thorac Cardiovasc Surg 2004;128:631-632
© 2004 The American Association for Thoracic Surgery

Brief communication

Acromegaly caused by ectopic growth hormone–releasing hormone secretion by a carcinoid bronchial tumor: A rare entity

Kalliopi Athanassiadi, MDa,*, Dimitrios Exarchos, MDb, Stylianos Tsagarakis, MDc, Ion Bellenis, MDa

a Department of Thoracic Surgery, "Evangelismos" General Hospital, Athens, Greece
b Department of Radiology, "Evangelismos" General Hospital, Athens, Greece
c Department of Endocrinology, "Evangelismos" General Hospital, Athens, Greece

Received for publication November 17, 2003; revisions received January 30, 2004; accepted for publication February 5, 2004.

* Address for reprits: Kalliopi Athanassiadi, MD, Konstantinoupoleosstr. 34A Holargos, 15562 Athens, Greece
kallatha@otenet.gr

The first 20% of the full text of this article appears below.

Ectopic secretion of growth hormone–releasing hormone (GHRH) is a rare cause of acromegaly.1-5 The most common tumors secreting GHRH are bronchial carcinoids and pancreatic islet cell tumors. Differential diagnosis of pituitary adenoma is necessary to avoid unnecessary pituitary surgery and damage to the pituitary gland. Rarely, that syndrome is secondary to a carcinoid bronchial tumor. We present a case of a synchronous GHRH-secreting bronchial carcinoid and a pituitary adenoma in a patient with acromegaly.

Clinical summary

A 37-year-old man who presented with an acromegaly over the last 8-year period was hospitalized in our department. He had been treated surgically for an acidophil pituitary adenoma 1 year ago, and the histology had revealed an adenoma (1.3 cm x 1.3 cm) producing growth hormone (GH) and prolactin. . . . [Full Text of this Article]






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