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Raja Joshi
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J Thorac Cardiovasc Surg 2005;129:209-210
© 2005 The American Association for Thoracic Surgery

Brief Communications

Increased expression of vascular endothelial growth factor messenger RNA in lungs of rats after cavopulmonary anastomosis

Muhammad A. Mumtaz, MDa, Charles H. Fraga, MSb, Chad M. Nicholls, MDb, Shailesh Desai, PhDa, Nikolay Vasilyev, MDa, Raja Joshi, MDa, Roger B.B. Mee, MB, ChB, FRACSa, Brian W. Duncan, MDa,*

a Department of Pediatric and Congenital Heart Surgery, The Children's Hospital at The Cleveland Clinic, Cleveland, Ohio
b Department of Surgery, The University of Washington, Seattle, Wash

Received for publication March 31, 2004; accepted for publication April 7, 2004.

* Address for reprints: Brian W. Duncan, MD, The Cleveland Clinic Foundation, Pediatric and Congenital Heart Surgery/M41, 9500 Euclid Ave, Cleveland, OH 44195 (E-mail: duncanb@ccf.org).

The first 20% of the full text of this article appears below.

Pulmonary arteriovenous malformations (PAVMs) are abnormal blood vessels that develop in a significant number of patients undergoing cavopulmonary anastomosis (CPA). PAVMs result in hypoxemia and decreased exercise tolerance from intrapulmonary right-to-left shunting. Histologically, PAVMs appear as numerous dilated and thin-walled vessels that extend far into the periphery of the pulmonary parenchyma.1,2 Vascular endothelial growth factor (VEGF) is an important mediator of both normal and abnormal vascular proliferation. We have demonstrated increased protein expression of VEGF and its receptor in the lungs of children after CPA.3 This study describes our attempts to measure VEGF messenger RNA (mRNA) expression in a rat model of PAVMs after CPA.


   Methods and results
 
Three male Sprague-Dawley . . . [Full Text of this Article]




This article has been cited by other articles:


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 J. Thorac. Cardiovasc. Surg.Home page
R. S. Tipps, M. Mumtaz, P. Leahy, and B. W. Duncan
Gene array analysis of a rat model of pulmonary arteriovenous malformations after superior cavopulmonary anastomosis.
J. Thorac. Cardiovasc. Surg., August 1, 2008; 136(2): 283 - 289.
[Abstract] [Full Text] [PDF]


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