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J Thorac Cardiovasc Surg 2005;129:937-938
© 2005 The American Association for Thoracic Surgery

Brief Communications

A cautionary note regarding long-term sequelae of biologic glue

^a Division of Cardiovascular Surgery, Mayo Clinic, Rochester, Minn
^b Division of Anatomic Pathology, Mayo Clinic, Rochester, Minn
^c Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minn

Received for publication July 16, 2004; accepted for publication July 21, 2004.

^_* Address for reprints: Thoralf M. Sundt, MD, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (E-mail: sundt.thoralf@mayo.edu).

The first 20% of the full text of this article appears below.

Postoperative hemorrhage remains a significant cause of mortality and morbidity after repair of acute aortic dissection. Accordingly, there has been great interest in the development and application of biologic hemostatic tissue sealants for use during this and other aortic surgical procedures.¹ Among these agents, BioGlue (Cryolife, Inc, Kennesaw, Ga) appears remarkably effective and has rapidly gained wide acceptance.^1,2 However, because it is composed of 45% (wt/vol) purified bovine albumin and 10% (wt/vol) glutaraldehyde in a 4:1 ratio, we have been concerned that it might not be completely innocuous. We have recently encountered a case of late anastomotic pseudoaneurysm potentially related to the use of BioGlue.

Clinical summary

During cardiologic evaluation of recurrent atrial flutter, a 76-year-old man was found to have a pseudoaneurysm of the ascending aorta. Two years previously, he had an acute type A dissection, for which he underwent graft replacement of the ascending aorta and hemiarch, as well as bioprosthetic aortic . . . [Full Text of this Article]

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