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J Thorac Cardiovasc Surg 2005;130:228-229
© 2005 The American Association for Thoracic Surgery

Brief Communication

Mediastinal-like growing teratoma syndrome

Massimiliano D’Aiuto, MD a , Giulia Veronesi, MD a , Fedro Alessandro Peccatori, MD b , Giuseppe Pelosi, MD c , Marco Venturino, MD d , Roberto Gasparri, MD a , Fabio Presicci, MD a , Domenico Galetta, MD a , Lorenzo Spaggiari, MD, PhD a , *

a Division of Thoracic Surgery, European Institute of Oncology, Milan, Italy.
b Division of Hematoncology, European Institute of Oncology, Milan, Italy.
c Division of Pathology, European Institute of Oncology, Milan, Italy.
d Division of Anesthesia, European Institute of Oncology, Milan, Italy.

Received for publication October 25, 2004; accepted for publication November 23, 2004.

* Address for reprints: Lorenzo Spaggiari, MD, PhD, Division of Thoracic Surgery, European Institute of Oncology, Via Ripamonti, 435, 20141 Milan, Italy. (Email: lorenzo.spaggiari@ieo.it).

The first 20% of the full text of this article appears below.

We present a case of a mediastinal-like growing teratoma syndrome (GTS) that occurred in a young man after 2 different lines of chemotherapy failed. The patient was successfully treated with a complete surgical resection of the giant mediastinal mass.

Clinical Summary

A 30-year-old man with a rapidly growing mediastinal tumor was referred to our attention after 2 lines of chemotherapy failed. The patient had been hospitalized 19 months prior for rapid onset of dyspnea. At that time, a total body computed tomography (CT) scan revealed an anterior mediastinal mass of 16 x 8 x 8 cm. No evidence of extrathoracic disease was found. Alpha-fetoprotein (AFP) was 3,027 ng/mL, whereas ß-human chorionic gonadotropin and serum carcinoembryonic antigen levels were normal. Fine-needle aspiration of the mediastinal mass revealed a nonseminomatous germ cell tumor.

The patient was then submitted to 2 different lines of chemotherapy (3 cycles of vinblastine, ifosfamide, and cisplatin [VeIP], followed by 4 cycles of ifosfamide, carboplatin, and etoposide, followed by rapid dimensional growth with the appearance of superior . . . [Full Text of this Article]






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