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J Thorac Cardiovasc Surg 2005;130:926-927
© 2005 The American Association for Thoracic Surgery

Brief Communication

Does donor catecholamine administration affect early lung function after transplantation?

Heart and Lung Transplantation Unit, University Hospital Birmingham, Birmingham, United Kingdom.

Received for publication December 30, 2004; accepted for publication February 3, 2005.

^_* Address for reprints: Robert S. Bonser, Department of Cardiothoracic Surgery, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Edgbaston, Birmingham B15 2TH, United Kingdom (Email: Robert.Bonser@uhb.nhs.uk).

The first 20% of the full text of this article appears below.

Cadaveric lung donors have a catecholamine storm of brain death, followed by proinflammatory cytokine response and subsequent pituitary failure. After the storm, a drop in circulating catecholamines and vasoparesis occur, ¹ and exogenous catecholamines are often administered to support systemic vascular resistance and maintain organ perfusion before retrieval.

The exogenous administration of catecholamines (EAC) to organ donors appears to improve outcome after renal and possibly liver transplantation, but in heart transplantation EAC is associated with a worse prognosis. ² EAC has been shown to increase alveolar fluid clearance after brainstem death, ³ but the impact on graft function and recipient outcome after lung transplantation is not known. We hypothesized that EAC might be beneficial in lung transplantation.

Patients and Methods

We retrospectively analyzed prospectively collected data from 60 consecutive lung transplant donors and recipients (June 1993 to September 2003). The PaO ₂/inspired oxygen fraction (FIO ₂) ratios at FIO ₂ 1.0 with 5 mm positive end-expiratory pressure immediately before retrieval were calculated. . . . [Full Text of this Article]

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