J Thorac Cardiovasc Surg 2005;130:1466-1467
© 2005 The American Association for Thoracic Surgery
The association of renal tubular acidosis and cyanotic congenital heart disease
Vladimiro L. Vida, MD
Ricardo Mack, MD
Joaquin Barnoya, MD, MPH
Luis A. Larrazabal, MD
Randal Lou, MD
Aldo R. Castañeda, MD, PhD
a Department of Pediatric Cardiovascular Surgery, UNICAR, Guatemala City, Guatemala.
b Department of Nephrology, Roosevelth National Hospital, Guatemala City, Guatemala.
Received for publication June 17, 2005; accepted for publication June 29, 2005.
* Address for reprints: Vladimiro L. Vida, MD, Department of Pediatric Cardiovascular Surgery of Guatemala, UNICAR, 9 avenida, 8-00 Zona 11 Guatemala City, Guatemala CA. (Email: firstname.lastname@example.org).
|The first 20% of the full text of this article appears below.|
Although late survival has been occasionally reported for patients with cyanotic congenital heart disease (CCHD), the complexity of the cardiac malformations and the complications of cyanosis prove often life-threatening at an early age.
It has been documented that chronic cyanosis affects renal glomerular structure and function, causing progressive glomerulopathy with eventual proteinuria.
Adverse effects of chronic hypoxia on renal tubular function have been less frequently documented.
Secondary renal tubular acidosis (sRTA) seems to be an acquired complication in patients with chronic cyanosis. The aim of this study was to evaluate the association of CCHD and renal tubular acidosis in a Guatemalan population.
Patients and Methods
Seventy-three of 110 patients with cyanosis (study group) with congenital heart disease were selected on the basis of an arterial oxygen saturation less than 80%. In these patients, arterial pH and blood gas values, as well as plasma anion gap (PAG) and urinary . . . [Full Text of this Article]
Copyright © 2005 by The American Association for Thoracic Surgery.