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J Thorac Cardiovasc Surg 2005;130:1475-1476
© 2005 The American Association for Thoracic Surgery

Brief Communication

Neuronal ultrastructure is preserved by fructose-1,6-bisphosphate after hypothermic circulatory arrest in pigs

Timo Kaakinen, MD a , * , Anita Naukkarinen, MSc, PhD b , Hannu Tuominen, MD, PhD c , Pekka Romsi, MD, PhD a , Matti Nuutinen, MD, PhD d , Fausto Biancari, MD, PhD a , Tatu Juvonen, MD, PhD a

a Department of Surgery, Oulu University Hospital, Clinical Research Center, University of Oulu, Oulu, Finland
c Department of Pathology, Oulu University Hospital, Clinical Research Center, University of Oulu, Oulu, Finland
d Department of Pediatrics, Oulu University Hospital, Clinical Research Center, University of Oulu, Oulu, Finland
b Department of Pathology, Kuopio University Hospital, Kuopio, Finland.

Received for publication June 13, 2005; revisions received July 7, 2005; accepted for publication July 12, 2005.

* Address for reprints: Timo Kaakinen, MD, Department of Surgery, Clinical Research Center, Oulu University Hospital, PO Box 21, 90029 OYS, Finland. (Email: timo.kaakinen@oulu.fi).

The first 20% of the full text of this article appears below.

In a previous study we have shown the neuroprotective efficacy of fructose-1,6-bisphosphate (FDP) during experimental hypothermic circulatory arrest in pigs. 1 Go In that study tissue samples from the left parietal cerebral cortex were obtained for electron microscopy analysis and examined later. Herein, we report the findings of that analysis.

Methods

Cerebral cortex biopsy specimens of 6 animals from the FDP group and 5 animals from the control group were chosen for electron microscopy analysis. All of these animals survived 7 days after the operation and were electively killed. Details of the experiment are reported in the main article. 1 Go The included animals in the FDP group were selected randomly. The cerebral samples (1- to 2-mm-thin sections) from the left parietal cortex were collected after the death of the animal on the 7th postoperative day. The samples were immediately fixed in a mixture of 1% glutaraldehyde and 4% formaldehyde in 0.1 mol/L phosphate buffer. The sections were further processed, examined, and photographed in a blinded fashion by a senior cell biologist (A.N.), who looked . . . [Full Text of this Article]




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