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J Thorac Cardiovasc Surg 2006;131:253
© 2006 The American Association for Thoracic Surgery

Letter to the Editor

Reply to the Editor

Department of Physiology and Pharmacology, James Cook University, Townsville, Queensland, Australia

The first 20% of the full text of this article appears below.

My colleagues and I thank Lange and colleagues for pointing out that we omitted mentioning the importance of volatile anesthetics and ischemic preconditioning (IPC) in a number of animal models and possibly human beings. For example, Kersten and coworkers ¹ showed that halothane preconditioning in barbiturate-anesthetized dogs led to a profound infarct size reduction (25.3% ± 2.9% to 11.8% ± 2.7%) and that this reduction was as effective as IPC (9.6% ± 2.0%). We were remiss in not discussing these results and their importance to IPC. Lange and colleagues also stated, "Anesthetic preconditioning significantly reduces arrhythmias after ischemic periods." The . . . [Full Text of this Article]