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J Thorac Cardiovasc Surg 2006;131:507-509
© 2006 The American Association for Thoracic Surgery

Letter to the Editor

Linking gene expression, nuclear factor kappa B, remote ischemic preconditioning, and transplantation: A quest for an elusive Holy Grail or a road to an amazing discovery?

Igor E. Konstantinov, MD, PhD, Andrew N. Redington, MD

Divisions of Cardiovascular Surgery and Cardiology, Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, M5G 1X8, Ontario, Canada

The first 20% of the full text of this article appears below.

To the Editor:

We read with interest the recent paper of Ishiyama and colleagues 1 Go reporting that inhibition of nuclear factor kappa B (NF-{kappa}B) by I{kappa}B supressor gene transfer ameliorated ischemia-reperfusion (IR) injury after experimental lung transplantation. A few comments seem appropriate.

Is activation of NF-{kappa}B before transplantation destructive or protective? Two murine studies provided seemingly contradictory results. In the study of Ishiyama and colleagues, 1 Go inhibition of NF-{kappa}B rendered protection against the IR injury, yet in another study 2 Go a targeted deletion of the p105 subunit of the NF-{kappa}B abolished the protective effect of the remote ischemic preconditioning (rIPC), a novel clinically applicable mode of . . . [Full Text of this Article]






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