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J Thorac Cardiovasc Surg 2006;131:1205-1206
© 2006 The American Association for Thoracic Surgery

Brief Communication

Duropleural fistula as a consequence of Gorham-Stout syndrome: A combination of 2 rare conditions

Ritwick Agrawal, MD a , Imran Mohammed, MD a , * , Patrick G. Reilly, MD b

a Department of Medicine, Mercy Hospital of Pittsburgh, Pittsburgh, Pa
b Department of Pulmonary and Critical Care, Mercy Hospital of Pittsburgh, Pittsburgh, Pa

Received for publication December 22, 2005; accepted for publication January 13, 2006.

* Address for reprints: Imran Mohammed, MD, Department of Medicine, Mercy Hospital of Pittsburgh, 1400 Locust St, Pittsburgh PA 15219 (Email: doc_imran@yahoo.com).

The first 20% of the full text of this article appears below.


Figure 1
R. Agrawal, P.G. Reilly, I. Mohammed (left to right)


Duropleural fistula (DPF) is an abnormal communication between the pleural and dural spaces caused by trauma, spinal surgery, or tumors. In our case it is caused by Gorham-Stout syndrome (GSS), a rare bone disease characterized by painless massive osteolysis caused by proliferation of lymphangiomatous tissue. The spinal form of GSS is associated with kyphosis, kyphoscoliosis, subluxation, and dislocation. DPF has never been previously described in association with GSS.

Clinical Summary

A 25-year-old woman with a history of Chiari I malformation was admitted with 2 days' duration of low-grade fever, fatigue, and dysphagia. Over the past 1 year, she had undergone multiple suboccipital craniotomies. Emergency magnetic resonance imaging of the brain did not show any change in size or dimension of the fourth ventricle. Physical examination was unremarkable except for dullness to percussion and rhonchi in the left lower lung fields. Chest radiography revealed a left lower lobe infiltrate and moderate left-sided pleural effusion. She was treated empirically with . . . [Full Text of this Article]




This article has been cited by other articles:


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F. Adler, N. Gupta, C. P. Hess, C. F. Dowd, and W. P. Dillon
Intraosseous CSF Fistula in a Patient with Gorham Disease Resulting in Intracranial Hypotension
AJNR Am. J. Neuroradiol., December 1, 2011; 32(11): E198 - E200.
[Abstract] [Full Text] [PDF]


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