JTCS KCI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Geny, B.
Right arrow Articles by Piquard, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Geny, B.
Right arrow Articles by Piquard, F.

J Thorac Cardiovasc Surg 2006;131:1417-1418
© 2006 The American Association for Thoracic Surgery

Brief Communication

Despite cardiac denervation, atrial natriuretic peptides possess a cardiac sympathoinhibitory effect after heart transplantation

Bernard Geny, MD, PhD * , Anne Charloux, MD, PhD, Gabrielle Brandenberger, PhD, Francois Piquard, PhD

Service de Physiologie et d'Explorations Fonctionnelles, Hôpitaux Universitaires et Institut de Physiologie, Faculté de Médecine, Strasbourg, France.

Received for publication January 3, 2006; accepted for publication January 24, 2006.

* Address for reprints: Bernard P. Geny, MD, PhD, 11 rur Humann, Strasbourg 67000, France. (Email: Bernard.Geny@physio-ulp.u-strasbg.fr).

The first 20% of the full text of this article appears below.

Heart transplantation is an excellent therapeutic alternative in end-stage heart failure, allowing a good survival for about half of heart transplant recipients until 15 years after surgical intervention.

However, surgically induced cardiac denervation increases the resting heart rate in heart transplant recipients through a withdrawal of the vagal tone. Blunting the heart rate reserve explains in part the reduced exercise capacity observed after heart transplantation. Additionally, with survival appearing to be inversely related to the degree of sympathetic activation and in particular to the noradrenergic drive to the diseased myocardium, 1 Go it might be very interesting to modulate peptides with cardiac sympathoinhibitory activity after heart transplantation.

Atrial natriuretic peptides (ANPs) might be a good candidate. Indeed, cardiac natriuretic peptides are important diagnostic and prognostic tools, and their therapeutic interest is growing because of their diuretic, natriuretic, and vasodilatory properties. Thus ANP infusion is useful in poorly responsive oliguria after cardiac surgery. 2 Go Moreover, importantly, ANPs possess sympathoinhibitory properties that might not only prevent against diuretic-induced sympathetic stimulation but that . . . [Full Text of this Article]




This article has been cited by other articles:


Home page
 Am J Clin NutrHome page
S. Doutreleau, O. Rouyer, P. Di Marco, E. Lonsdorfer, R. Richard, F. Piquard, and B. Geny
L-Arginine supplementation improves exercise capacity after a heart transplant
Am J Clin Nutr, May 1, 2010; 91(5): 1261 - 1267.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Rebuttal from Drs. Richard, Zoll, Mettauer, Piquard, and Geny
J Appl Physiol, February 1, 2008; 104(2): 563 - 564.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2006 by The American Association for Thoracic Surgery.