JTCS KCI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Shigefumi Suehiro
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Iwata, T.
Right arrow Articles by Suehiro, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iwata, T.
Right arrow Articles by Suehiro, S.
Related Collections
Right arrow Mediastinum

J Thorac Cardiovasc Surg 2006;132:196-197
© 2006 The American Association for Thoracic Surgery

Brief Communication

Thymectomy for paraneoplastic stiff-person syndrome associated with invasive thymoma

Takashi Iwata, MD a , * , Kiyotoshi Inoue, MD a , Shinjiro Mizuguchi, MD a , Ryuhei Morita, MD a , Takuma Tsukioka, MD a , Shigefumi Suehiro, MD b

a Department of Thoracic Surgery, Osaka City University Hospital, Osaka, Japan
b Department of Cardiovascular Surgery, Osaka City University Hospital, Osaka, Japan

* Address for reprints: Takashi Iwata, MD, Department of Thoracic Surgery, Osaka City University Hospital, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585 Japan. (Email: taiwata@med.osaka-cu.ac.jp).

The first 20% of the full text of this article appears below.


Figure 1
Drs Morita, Mizuguchi, Inoue, Iwata, and Tsukioka (left to right)


Stiff-person syndrome (SPS) is a rare autoimmune neurologic disorder characterized by painful tonic spasms in systemic skeletal muscles. 1 Go Anti-glutaminic acid decarboxylase (GAD) antibodies are produced with disturbing synthesis of {gamma}-aminobutylic acid, one of the important suppressive neurotransmitters in the central nervous system. In some patients SPS is reportedly accompanied by thymomas, 2-4 Go and in these patients surgical resection of the malignancy reportedly reduces the neurologic symptoms of SPS. We report herein the clinical course of a patient with SPS associated with invasive thymoma.

Clinical Summary

A 79-year-old woman presented with severe, painful tonic spasms of her left leg as a result of a fall. Conservative therapy by an orthopedic surgeon subdued the leg pain for 2 weeks; however, stiffness remained. After this, her voice began to become unclear, and she complained of dysarthria. She lost 10 kg in weight in 3 months. She was therefore referred to a neurologist in our hospital. She was . . . [Full Text of this Article]




This article has been cited by other articles:


Home page
 Arch NeurolHome page
A. McKeon, M. T. Robinson, K. M. McEvoy, J. Y. Matsumoto, V. A. Lennon, J. E. Ahlskog, and S. J. Pittock
Stiff-Man Syndrome and Variants: Clinical Course, Treatments, and Outcomes
Arch Neurol, February 1, 2012; 69(2): 230 - 238.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2006 by The American Association for Thoracic Surgery.