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J Thorac Cardiovasc Surg 2006;132:685-686
© 2006 The American Association for Thoracic Surgery

Brief Communication

Temporary internal thoracic artery occlusion during off-pump coronary artery bypass grafting with the new poloxamer P407 does not cause endothelial dysfunction

Marie-Claude Aubin, MSca, Olivier Bouchot, MDb, Michel Carrier, MDc, William E. Cohn, MDd, Louis P. Perrault, MD, PhDa,c,*

a Department of Pharmacology, Université de Montréal, Montreal, Quebec, Canada
b Department of Cardiovascular Surgery, Le Bocage Hospital, Dijon, France
c Department of Surgery, Montreal Heart Institute and Université de Montréal, and the Department of Pharmacology, Université de Montréal, Montreal, Quebec, Canada
d Department of Surgery, Texas Heart Institute, Houston, Tex.

Received for publication March 29, 2006; accepted for publication May 9, 2006.

* Address for reprints: Louis P. Perrault, MD, PhD, Research Center, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec, H1T 1C8, Canada (Email: louis.perrault@icm-mhi.org).

The first 20% of the full text of this article appears below.


Figure 1
Dr Perrault


The positive effects of coronary revascularization are now well established. However, the application of vascular clamps to achieve a bloodless field during the anastomosis might alter the integrity of the internal thoracic artery.1Go The reverse thermosensitive formulation of the poloxamer 407 (P407) makes it attractive for temporary vascular occlusion because it only solidifies when in contact with body temperature.2Go Therefore, the purpose of this study was to assess the effect of occlusion with P407 on internal thoracic artery endothelium function.

Methods

Surgical procedure
The chests of 9 Landrace swine of either sex (25 ± 4 kg) were entered through a median sternotomy.3Go The left internal thoracic artery was harvested as a pedicle from the subclavian artery. After distal section, the blood flow was controlled by means of proximal finger compression. P407 (20%, 200 µL) was injected with a Cardiac Control Syringe (Pluromed Inc, Woburn, Mass) . . . [Full Text of this Article]






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