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J Thorac Cardiovasc Surg 2006;132:722-723
© 2006 The American Association for Thoracic Surgery


Brief Communication

Urine drug testing in an athlete leads to the diagnosis of unsuspected mediastinal germ cell tumor

Andrew E. Newcomb, MBBSa,*, C. Peter Clarke, FRACSa, Cherie Y. Chiang, MBBSb, George Jerums, FRACPb

a Department of Thoracic Surgery, Austin Hospital, Melbourne, Australia.
b Department of Endocrinology, Austin Hospital, Melbourne, Australia.

Received for publication March 14, 2006; accepted for publication April 20, 2006.

* Address for reprints: Andrew Newcomb, MBBS, Department of Thoracic Surgery, Austin Hospital, Studley Rd, Heidelberg, Victoria 3082, Australia (Email: anewcomb@amavic.com).

The first 20% of the full text of this article appears below.

Mediastinal seminoma is an uncommon malignancy. We present the case of a 17-year-old weightlifter given a diagnosis as a result of routine urine drug screening.

Clinical Summary

This competition weightlifter was referred to an endocrinologist after a positive ß-human chorionic gonadotropin (HCG) result on routine urine screening (B sample). He was asymptomatic and denied illicit drug use. Blood tests confirmed an increase in ß-HCG levels, with decreased leutenizing hormone and follicle-stimulating hormone levels and also increased testosterone levels (Table 1). Examination, including testicular assessment with ultrasonography, was unremarkable, and an extragonadal germ cell tumor was suspected. Computed tomographic scanning of the chest, abdomen, and pelvis was performed and showed a 33-mm anterior mediastinal mass (Figure 1, A). This showed fluoro-deoxy glucose avidity on positron emission tomography (Figure 1, B). . . . [Full Text of this Article]







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